Doctoral themes 2023

Sustainable synthesis of anticancer agents using novel electrochemical methods 

Supervisors

Jaime A. S. Coelho, jacoelho@ciencias.ulisboa.pt

Tânia S. Morais, tsmorais@ciencias.ulisboa.pt

Registration Institution

Faculdade de Ciências, Universidade de Lisboa

Project description

Cancer continues to be a major public health concern, responsible for approximately 9.6 million deaths worldwide in 2020 and impacting the lives of many individuals. This disease not only poses significant challenges for patients but also has a considerable economic impact on healthcare systems worldwide, highlighting the urgent need for continued research and innovation in cancer treatment. Development of new drugs with improved efficacy and safety profiles remains a key goal in cancer research. To this end, the present PhD project aims to develop novel organic molecules with potential anticancer activity, using novel mediated electrochemical methodologies, including metal-based redox mediators. The synthesized compounds will be assessed for their anticancer activity using various assays, with the goal of identifying novel and effective drug candidates (ongoing collaboration with FFUL). A short-term visit to University of Padova (Italy) is envisioned to explore sustainable synthetic redox methodologies

Keywords

Cancer

Anticancer agents

Electrochemistry

Sustainability

Synthesis