Doctoral Themes - Proposals

Porous materials for the adsorption and release of molecules with therapeutic effect

Supervisors

João Pires da Silva, jpsilva@ciencias.ulisboa.pt

Registration Institution

Faculdade de Ciências (Universidade de Lisboa)

Project description

There are gaseous molecules that have important therapeutic effects for various diseases. However, because they are gases, their administration is complex. Porous materials (eg zeolites or MOFs - “Metal-Organic Frameworks”) are a promising alternative as they allow the storage, and later release, of these molecules with therapeutic action.

References

- https://webpages.ciencias.ulisboa.pt/~jpsilva/

- Rosana V. Pinto, Sujing Wang, Sergio R. Tavares, João Pires, Fernando Antunes, Alexandre Vimont, Guillaume Clet, Marco Daturi, Guillaume Maurin, Christian Serre, Moisés L. Pinto Tuning Cellular Biological Functions Through the Controlled Release of NO from a Porous Ti-MOF Angewandte Chemie International Edition 59 (2020) 5135-5143.

-Rosana V. Pinto, Ana C. Fernandes, Fernando Antunes, Zhi Lin, João Rocha, João Pires, Moisés L. Pinto New Generation of Nitric Oxide-Releasing Porous Materials: Assessment of their Potential to Regulate Biological Functions Nitric Oxide 90 (2019) 29-36.

- Ana C. Fernandes, Moisés L. Pinto, Fernando Antunes, João Pires Synthetic Cobalt Clays for the Storage and Slow Release of Therapeutic Nitric Oxide RSC Advances 6 (2016) 41195-41203

Keywords

Porous-materials; adsorption; drug release

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