Publication Type Journal Article
Title Antimicrobial Activity of Pyrazinamide Coordination Frameworks Synthesized by Mechanochemistry
Authors Silvia Quaresma Paula C. Alves Patricia Rijo M. Teresa Duarte Vânia André
Groups BIOMOL
Journal MOLECULES
Year 2021
Month April
Volume 26
Number 7
Pages
Abstract The urge for the development of a more efficient antibiotic crystalline forms led us to the disclosure of new antibiotic coordination frameworks of pyrazinamide, a well-known drug used for the treatment of tuberculosis, with some of the novel compounds unravelling improved antimycobacterial activity. Mechanochemistry was the preferred synthetic technique to yield novel compounds, allowing the reproduction of a 1D zinc framework, the synthesis of a novel hydrogen bonding manganese framework, and three new compounds with silver. The structural characterization of the novel forms is presented along with stability studies. The increased antimicrobial activity of the new silver-based frameworks against Escherichia coli, Staphylococcus aureus, and Mycobacterium smegmatis is particularly relevant.
DOI http://dx.doi.org/10.3390/molecules26071904
ISBN
Publisher
Book Title
ISSN
EISSN 1420-3049
Conference Name
Bibtex ID ISI:000638742700001
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