| Publication Type |
Journal Article |
| Title |
Synthesis of Substituted 4-Arylamine-1,2-naphthoquinones in One-Pot Reactions Using CotA-Laccase as Biocatalyst |
| Authors |
Ana Catarina Cardoso de Sousa Iolanda Santos M. F. M. M. Piedade Ligia O. Martins M Paula Robalo |
| Groups |
BioMol |
| Journal |
ADVANCED SYNTHESIS \& CATALYSIS |
| Year |
2020 |
| Month |
August |
| Volume |
362 |
| Number |
16 |
| Pages |
3380-3387 |
| Abstract |
An efficient and environmentally benign biocatalytic strategy for the synthesis of substituted 4-arylamino-1,2-naphthoquinones was developed, through a cross-coupling reaction in which the 1,2-naphthoquinone nucleus, formed in the biocatalytic process mediated by CotA-laccase from Bacillus subtilis, is the key synthetic intermediate. Electrochemical data and kinetic parameters were determined revealing a significant higher specificity of CotA-laccase for 4-amino-3-hydroxynaphthalene-1-sulfonic acid (AHNSA). This ability of CotA-laccase to discriminate between oxidisable aromatic amines allows the set-up of one-pot reactions in the presence of the enzyme, between AHNSA and a set of appropriate aromatic amines under mild reaction conditions. |
| DOI |
http://dx.doi.org/10.1002/adsc.202000082 |
| ISBN |
|
| Publisher |
WILEY-V C H VERLAG GMBH |
| Book Title |
|
| ISSN |
1615-4150 |
| EISSN |
1615-4169 |
| Conference Name |
|
| Bibtex ID |
ISI:000531345800001 |
| Observations |
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