| Publication Type |
Journal Article |
| Title |
Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors |
| Authors |
Mohamed Y. Mahgoub Awatef M. Elmaghraby Abd-Elfttah A. Harb João Ferreira da Silva Gonçalo C. Justino M. Matilde Marques |
| Groups |
BioMol |
| Journal |
MOLECULES |
| Year |
2019 |
| Month |
June |
| Volume |
24 |
| Number |
12 |
| Pages |
|
| Abstract |
A new series of thiazolo[3,2-a]pyrimidine bromide salt derivatives 7a-d were synthesized from 3,4-dihydropyrimidinethione precursors. The target compounds were fully characterized by 1D- and 2D-NMR, high resolution ESI-MS/MS and single crystal X-ray diffraction analysis, which confirmed a regioselective 5H cyclization of the dihydropyrimidinethiones. All target compounds were evaluated in vitro as human acetylcholinesterase (hAChE) inhibitors via an Ellman-based colorimetric assay and showed good inhibition activities (better than 70\% at 10 mu M and IC50 values in the 1 mu M range). Molecular docking simulations for all target products into hAChE were performed and confirmed strong binding to the enzyme. These results provide a promising and new starting point to improve acetylcholinesterase inhibitors and explore novel treatment options against Alzheimer s disease. |
| DOI |
http://dx.doi.org/10.3390/molecules24122306 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
1420-3049 |
| EISSN |
|
| Conference Name |
|
| Bibtex ID |
ISI:000473816900112 |
| Observations |
|
