| Publication Type |
Journal Article |
| Title |
Plasma Ribavirin Trough Concentrations at Week 4 Predict Hepatitis C Virus (HCV) Relapse in HIV-HCV-Coinfected Patients Treated for Chronic Hepatitis C |
| Authors |
Judit Morello Vincent Soriano Pablo Barreiro Jose Medrano Antonio Madejon Gema Gonzalez-Pardo Inmaculada Jimenez-Nacher Juan Gonzalez-Lahoz Sonia Rodriguez-Novoa |
| Groups |
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| Journal |
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY |
| Year |
2010 |
| Month |
April |
| Volume |
54 |
| Number |
4 |
| Pages |
1647-1649 |
| Abstract |
The influence of ribavirin trough concentrations (RBV C(trough)) on the risk of hepatitis C virus (HCV) relapse was retrospectively analyzed in 99 HIV-HCV-coinfected patients who achieved end-of-treatment response with pegylated alpha interferon plus weight-based RBV. The independent predictors (odds ratio [OR] [95\% confidence interval (CI)]) of HCV relapse were RBV plasma C(trough) of < 2.5 mu g/ml (4.5 [1.3 to 15.5]), baseline serum HCV RNA (2.5 [1.2 to 5.1]), and HCV genotype 1 or 4 (13.3 [2.6 to 66.7]). Monitoring of RBV C(trough) may permit early adjustment of RBV dosage to avoid HCV relapse. |
| DOI |
http://dx.doi.org/10.1128/AAC.01399-09 |
| ISBN |
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| Publisher |
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| Book Title |
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| ISSN |
0066-4804 |
| EISSN |
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| Conference Name |
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| Bibtex ID |
ISI:000275662700038 |
| Observations |
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