| Publication Type |
Journal Article |
| Title |
POxylated Polyurea Dendrimers: Smart Core-Shell Vectors with IC50 Lowering Capacity |
| Authors |
Rita B. Restani Joao Conde Rita F. Pires Pedro Martins A.R. Fernandes Pedro V. Baptista Vasco D. B. Bonifacio Ana Aguiar-Ricardo |
| Groups |
|
| Journal |
MACROMOLECULAR BIOSCIENCE |
| Year |
2015 |
| Month |
August |
| Volume |
15 |
| Number |
8 |
| Pages |
1045-1051 |
| Abstract |
The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-soluble core-shell smart nanocarriers show low toxicity in terms of cell viability and absence of glutathione depletion, two of the major side effect limitations of current vectors. The materials are also found to act as good transfection agents, through a mechanism involving an endosomal pathway, being able to reduce 100-fold the IC50 of paclitaxel. |
| DOI |
http://dx.doi.org/10.1002/mabi.201500131 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
1616-5187 |
| EISSN |
1616-5195 |
| Conference Name |
|
| Bibtex ID |
ISI:000359629600002 |
| Observations |
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