Publication Type |
Journal Article |
Title |
Synthesis of a Biologically Active Oxazol-5-(4H)-one via an Erlenmeyer-Plochl Reaction |
Authors |
C. Rodrigues J. M. G. Martinho Carlos A. M. Afonso |
Groups |
|
Journal |
JOURNAL OF CHEMICAL EDUCATION |
Year |
2015 |
Month |
September |
Volume |
92 |
Number |
9 |
Pages |
1543-1546 |
Abstract |
The synthesis of (Z)-4-(4-nitrobenzylidene)-2-phenyloxazol-5(4H)-one, which is a potent immunomodulator and tyrosinase inhibitor, is described as an experiment for an upper-division undergraduate organic chemistry laboratory course. This compound is produced via an Erlenmeyer-Plochl reaction in the absence Of any additional solvents and is isolated without need of preparative chromatography, yielding up to 97\% of product. |
DOI |
http://dx.doi.org/10.1021/ed500212t |
ISBN |
|
Publisher |
|
Book Title |
|
ISSN |
0021-9584 |
EISSN |
1938-1328 |
Conference Name |
|
Bibtex ID |
ISI:000361580200020 |
Observations |
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