Publication Type |
Journal Article |
Title |
Direct experimental observation of the aggregation of alpha-amino acids into 100-200 nm clusters in aqueous solution |
Authors |
Daniel Hagmeyer Johannes Ruesing Tassilo Fenske Heinz-Werner Klein Carsten Schmuck Wolfgang Schrader M. E. M. Piedade Matthias Epple |
Groups |
MET |
Journal |
RSC ADVANCES |
Year |
2012 |
Month |
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|
Volume |
2 |
Number |
11 |
Pages |
4690-4696 |
Abstract |
Spherical supramolecular aggregates of alpha-amino acids with a typical diameter of 100-200 nm are formed spontaneously after dissolution in water at a concentration of a few mM, i.e. well below the solubility limit. Their presence was shown by nanoparticle tracking analysis (NTA), atomic force microscopy (AFM), and ESI mass spectrometry (ESI-MS). There is a dynamic equilibrium between the aggregates and dissolved individual molecules which allows them to penetrate through dialysis membranes and filters. The same phenomenon was observed for para-amino salicylic acid and two dipeptides. Thermodynamic considerations suggest an entropy-controlled process. |
DOI |
http://dx.doi.org/10.1039/c2ra01352e |
ISBN |
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Publisher |
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Book Title |
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ISSN |
2046-2069 |
EISSN |
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Conference Name |
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Bibtex ID |
ISI:000304148400022 |
Observations |
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