| Abstract |
Plectranthus barbatus, known as falso boldo in Brazil, is used in herbal tea or cooked as a vegetable. Infusions and decoctions of leaves from P. barbatus were analysed for their inhibition of acetylcholinesterase and their antioxidant activity. The decoction showed high inhibition activity (31\% inhibition with 0.5 mg of extract/ml) and also high antioxidant activity (IC(50) = 45.8 +/- 0.5 mu g of dry extract/ml in the DPPH test; IC50 = 69.8 +/- 3.1 mu g of dry extract/ml in the beta-carotene-linoleic acid test). Rosmarinic acid, scutellarein 4 -methyl ether 7-O-glucuronide and (16S)-coleon E were the main constituents identified. These compounds have antiacetylcholinesterase activity. Rosmarinic acid and the scutellarein derivative have IC(50)=440 mu g/ml and 1 mg/ml, respectively. One milligram per millilitre of(16S)-coleon E showed 61\% inhibition of the enzyme. Other Plectranthus species. P. ecklonii, P. fructicosus, P. lanuginosus and P. verticillatus, were also analysed and the results obtained correlated with the content in rosmarinic acid. (C) 2008 Elsevier Ltd. All rights reserved. |
