| Publication Type |
Journal Article |
| Title |
12,17-Cyclojatrophane and Jatrophane Constituents of Euphorbia welwitschiie |
| Authors |
Mariana A. Reis Vânia André M. Teresa Duarte Hermann Lage Maria-Jose U. Ferreira |
| Groups |
BioMol |
| Journal |
JOURNAL OF NATURAL PRODUCTS |
| Year |
2015 |
| Month |
November |
| Volume |
78 |
| Number |
11 |
| Pages |
2684-2690 |
| Abstract |
Euphowelwitschines A (1) and B (2), isolated from a methanolic extract of Euphorbia welwitschii, exhibit a rare combination of structural features in having a 5/8/8 fused-ring system and a 12,15-ether bridge. Moreover, the isolation of the additional new compounds welwitschene (3) and epoxywelwitschene (4) has provided insights into the biogenetic pathway of 12,17-cyclojatrophanes. The structures of 1-4 were determined by spectroscopic methods inclusive of 1D and 2D NMR experiments and X-ray crystallography for compounds 1 and 2. Preliminary information on the selective antiproliferative activity of compounds 1-4 is also described. |
| DOI |
http://dx.doi.org/10.1021/acs.jnatprod.5b00631 |
| ISBN |
|
| Publisher |
AMER CHEMICAL SOC |
| Book Title |
|
| ISSN |
0163-3864 |
| EISSN |
1520-6025 |
| Conference Name |
|
| Bibtex ID |
ISI:000366005800022 |
| Observations |
|
