| Publication Type |
Journal Article |
| Title |
Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients |
| Authors |
Nadia M. Grilo M. Joao Correia Catarina Sequeira Shrika G. Harjivan Umbelina Caixas Lucilia N. Diogo M. Matilde Marques Emilia C. Monteiro Alexandra Maria Moita Antunes Sofia A. Pereira |
| Groups |
BioMol |
| Journal |
TOXICOLOGY LETTERS |
| Year |
2016 |
| Month |
October |
| Volume |
260 |
| Number |
|
| Pages |
28-35 |
| Abstract |
Efavirenz is a drug of choice for adults and children infected with the human immunodeficiency virus. Notably, up to 35\% of patients on efavirenz suffer from mood changes. This work aimed to investigate efavirenz biotransformation into 8-hydroxy-efavirenz as an up-stream event of mood changes and to evaluate the suitability of 8-hydroxy-efavirenz biomonitoring for the minimization of these manifestations. A case-control study with two age-matched groups of HIV-infected male patients was performed in a group without adverse central nervous system complaints (28 patients) and a group presenting mood changes (14 patients). The plasma concentration of non-conjugated 8-hydroxy-efavirenz was higher in |
| DOI |
http://dx.doi.org/10.1016/j.toxlet.2016.08.009 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
0378-4274 |
| EISSN |
1879-3169 |
| Conference Name |
|
| Bibtex ID |
ISI:000385528900004 |
| Observations |
|
