A new journal cover was featured on Inorg. Chem. 2024, 63, 37, 17087–17099. This paper presents the synthesis of three novel metal-based compounds, incorporating gold (Au), copper (Cu), and silver (Ag) with the antimalarial naphthoquinone, atovaquone, as a reference compound for malaria treatment. Single-crystal X-ray diffraction analysis reveals a structure-activity relationship, suggesting that the antimalarial efficacy of atovaquone is influenced by its redox state, and that metal coordination can modulate both its molecular and cellular interactions. This study pioneers the development of metal-based therapeutics for malaria.
