M. Helena Garcia is Associate Professor with “Habilitation” at University of Lisbon (FCUL) jubilated by 31 of May of 2017. Since then she got a collaboration agreement with FCUL where she continues her leadership on the Organometallic Research Laboratory, working on the synthesis of organometallic compounds for cancer therapy. M. Helena Garcia is the leader of a FCUL spin-off company named ´HATIcancer` and she is co-author of several national and international patents. She authored over one hundred and twenty international peer reviewed scientific papers and book chapters. M. Helena Garcia has been leader of several national and European funded scientific research projects and was Member of the “Division of Organometallic Chemistry” of European Association Chemical and Molecular Sciences, as delegate of Portuguese Chemical Society, in the period 1992-2017. She was for many years the Coordinator of the International Office at Faculty of Sciences of University of Lisbon.

Selected Papers

First polymer ruthenium-cyclopentadienyl complex as potential anticancer agent
JOURNAL OF INORGANIC BIOCHEMISTRY, 127, 79-81 10 2013
Andreia Valente , M. Helena Garcia , Fernanda M. Marques , Yong Miao , Cyril Rousseau , Philippe Zinck

Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 19, 853-867 8 2014
Leonor Côrte-Real , Filipa Mendes , Joana Coimbra , Tânia S. Morais , Ana Isabel Tomaz , Andreia Valente , M. Helena Garcia , Isabel Santos , Manuel Bicho , Fernanda M. Marques

New iron cyclopentadienyl complexes bearing different phosphane co-ligands: Structural factors vs. cytotoxicity
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 852, 34-42 12 2017
Adhan Pilon , Patricia Girio , Guilherme Nogueira , Fernando Avecilla , Harry Adams , Julia Lorenzo , M. Helena Garcia , Andreia Valente

Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands
BIOINORGANIC CHEMISTRY AND APPLICATIONS, , 2010
Virtudes Moreno , Julia Lorenzo , Francesc X. Aviles , M. Helena Garcia , Joao P. Ribeiro , Tânia S. Morais , Pedro Florindo , M Paula Robalo

DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands
JOURNAL OF INORGANIC BIOCHEMISTRY, 105, 241-249 2 2011
Virtudes Moreno , Merce Font-Bardia , Teresa Calvet , Julia Lorenzo , Francesc X. Aviles , M. Helena Garcia , Tânia S. Morais , Andreia Valente , M Paula Robalo

Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
JOURNAL OF INORGANIC BIOCHEMISTRY, 114, 65-74 9 2012
Tânia S. Morais , Tiago J. L. Silva , Fernanda M. Marques , M Paula Robalo , Fernando Avecilla , Paulo J. Amorim Madeira , Paulo Mendes , Isabel Santos , M. Helena Garcia

[Ru-II(eta(5)-C5H5)(bipy)(PPh3)](+), a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin
JOURNAL OF INORGANIC BIOCHEMISTRY, 117, 261-269 12 2012
Ana Isabel Tomaz , Tamas Jakusch , Tânia S. Morais , Fernanda M. Marques , R. F. M. de Almeida , Filipa Mendes , Eva A. Enyedy , Isabel Santos , J.C. Pessoa , Tamas Kiss , M. Helena Garcia

New polydentate Ru(III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins
INORGANICA CHIMICA ACTA, 394, 616-626 1 2013
Cristina P. Matos , Andreia Valente , Fernanda M. Marques , Pedro Adão , M Paula Robalo , R. F. M. de Almeida , J.C. Pessoa , Isabel Santos , M. Helena Garcia , Ana Isabel Tomaz

A novel (VO)-O-IV-pyrimidinone complex: synthesis, solution speciation and human serum protein binding
DALTON TRANSACTIONS, 42, 11841-11861 2013
Gisela Goncalves , Ana Isabel Tomaz , Isabel Correia , Luis F. Veiros , M. Margarida C. A. Castro , Fernando Avecilla , Lorena Palacio , Miguel Maestro , Tamas Kiss , Tamas Jakusch , M. Helena Garcia , J.C. Pessoa

Biological activity and cellular uptake of [Ru(eta(5)-C5H5)(PPh3)(Me(2)bpy)][CF3SO3] complex
JOURNAL OF INORGANIC BIOCHEMISTRY, 122, 8-17 5 2013
Tânia S. Morais , Filipa C. Santos , Leonor Côrte-Real , Fernanda M. Marques , M Paula Robalo , Paulo J. Amorim Madeira , M. Helena Garcia

Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands
JOURNAL OF INORGANIC BIOCHEMISTRY, 129, 1-8 12 2013
Ana Cristina Goncalves , Tânia S. Morais , M Paula Robalo , Fernanda M. Marques , Fernando Avecilla , Cristina P. Matos , Isabel Santos , Ana Isabel Tomaz , M. Helena Garcia

New water-soluble ruthenium(II) cytotoxic complex: Biological activity and cellular distribution
JOURNAL OF INORGANIC BIOCHEMISTRY, 130, 1-14 1 2014
Tânia S. Morais , Filipa C. Santos , Tiago F. Jorge , Leonor Côrte-Real , Paulo J. Amorim Madeira , Fernanda M. Marques , M Paula Robalo , Antonio Matos , Isabel Santos , M. Helena Garcia

New iron(II) cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leukemia cancer cells
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 756, 52-60 4 2014
Andreia Valente , Ana Margarida Santos , Leonor Côrte-Real , M Paula Robalo , Virtudes Moreno , Merce Font-Bardia , Teresa Calvet , Julia Lorenzo , M. Helena Garcia

The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds
JOURNAL OF INORGANIC BIOCHEMISTRY, 150, 148-159 9 2015
Leonor Côrte-Real , M Paula Robalo , Fernanda M. Marques , Guilherme Nogueira , Fernando Avecilla , Tiago J. L. Silva , Filipa C. Santos , Ana Isabel Tomaz , M. Helena Garcia , Andreia Valente

Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites
JOURNAL OF INORGANIC BIOCHEMISTRY, 153, 306-314 12 2015
Mariana Fernandez , Esteban Rodriguez Arce , Cynthia Sarniguet , Tânia S. Morais , Ana Isabel Tomaz , Claudio Olea Azar , Roberto Figueroa , J. Diego Maya , Andrea Medeiros , Marcelo Comini , M. Helena Garcia , Lucia Otero , Dinorah Gambino

Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds
FUTURE MEDICINAL CHEMISTRY, 8, 527-544 2016
Tânia S. Morais , Andreia Valente , Ana Isabel Tomaz , Fernanda M. Marques , M. Helena Garcia

In Vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 17, 126-136 2017
Nuno Mendes , Francisco Tortosa , Andreia Valente , Fernanda M. Marques , Antonio Matos , Tânia S. Morais , Ana Isabel Tomaz , Fatima Gartner , M. Helena Garcia

Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands
JOURNAL OF INORGANIC BIOCHEMISTRY, 103, 354-361 3 2009
M. Helena Garcia , Tânia S. Morais , Pedro Florindo , M.Fatima M.Piedade , Virtudes Moreno , Carlos Ciudad , Veronica Noe

New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy
INORGANICA CHIMICA ACTA, 363, 3765-3775 11 2010
M. Helena Garcia , Andreia Valente , Pedro Florindo , Tânia S. Morais , M.Fatima M.Piedade , M. Teresa Duarte , Virtudes Moreno , Francesc X. Aviles , Julia Loreno

New copper(I) and heteronuclear copper(I)-ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity
JOURNAL OF INORGANIC BIOCHEMISTRY, 169, 68-78 4 2017
Joao Lopes , David Alves , Tânia S. Morais , Paulo J. Costa , M.Fatima M.Piedade , Fernanda M. Marques , Maria J. Villa de Brito , M. Helena Garcia

Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes
JOURNAL OF INORGANIC BIOCHEMISTRY, 168, 27-37 3 2017
Orsolya Doemoetoer , R. F. M. de Almeida , Leonor Côrte-Real , Cristina P. Matos , Fernanda M. Marques , Antonio Matos , Carla Real , Tamas Kiss , Eve Anna Enyedy , M. Helena Garcia , Ana Isabel Tomaz