Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer s drug candidates
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 33, 1212-1224 8 2018
Luca Piemontese , Daniel Tomás , Asha Hiremathad , Vito Capriati , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies
NEW JOURNAL OF CHEMISTRY, 42, 8050-8061 5 2018
Rosita Cappai , Karam Chand , Joanna I. Lachowicz , Sílvia Chaves , Lurdes Gano , G. Crisponi , V. M. Nurchi , M. Peana , Maria Antonietta Zoroddu , M. Amélia Santos

Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer s drug candidates
RSC ADVANCES, 6, 53519-53532 2016
Asha Hiremathad , Karam Chand , A. Raquel Esteves , Sandra M. Cardoso , Rona R. Ramsay , Sílvia Chaves , Rangappa S. Keri , M. Amélia Santos

New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer s Disease
CHEMICAL BIOLOGY \& DRUG DESIGN, 87, 101-111 1 2016
Rangappa S. Keri , Catarina Quintanova , Sílvia Chaves , Diana F. Silva , Sandra M. Cardoso , M. Amélia Santos

Recent progress in repositioning Alzheimer s disease drugs based on a multitarget strategy
FUTURE MEDICINAL CHEMISTRY, 8, 2113-2142 11 2016
M. Amélia Santos , Karam Chand , Sílvia Chaves

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer s agents: AChE inhibition, antioxidant activity and metal chelating capacity
JOURNAL OF INORGANIC BIOCHEMISTRY, 163, 266-277 10 2016
Karam Chand , Hesham M. Alsoghier , Sílvia Chaves , M. Amélia Santos

Recent progress in multifunctional metal chelators as potential drugs for Alzheimer s disease
COORDINATION CHEMISTRY REVIEWS, 327, 287-303 11 2016
M. Amélia Santos , Karam Chand , Sílvia Chaves

Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles
JOURNAL OF INORGANIC BIOCHEMISTRY, 151, 58-66 10 2015
Catarina Quintanova , Rangappa S. Keri , Sílvia Chaves , M. Amélia Santos

3-hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use
FUTURE MEDICINAL CHEMISTRY, 7, 383-410 2015
M. Amélia Santos , Sílvia Chaves

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy
JOURNAL OF INORGANIC BIOCHEMISTRY, 127, 188-202 10 2013
Sergio M. Marques , Claudia C. Abate , Sílvia Chaves , Fernanda M. Marques , Isabel Santos , Elisa Nuti , Armando Rossello , M. Amélia Santos

A novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: synthesis, complexation and in vivo studies
DALTON TRANSACTIONS, 42, 6033-6045 2013
Sílvia Chaves , Anabela Capelo , Laurinda Areias , Sergio M. Marques , Lurdes Gano , M. Alexandra Esteves , M. Amélia Santos

New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties
DALTON TRANSACTIONS, 42, 6046-6057 2013
Ana C. Mendonca , Andre F. Martins , Andrea Melchior , Sergio M. Marques , Sílvia Chaves , Sandrine Villette , Stephane Petoud , Pier Luigi Zanonato , Marilena Tolazzi , Celia S. Bonnet , Eva Toth , Plinio Di Bernardo , Carlos F. G. C. Geraldes , M. Amélia Santos

Multifunctional iron- chelators with protective roles against neurodegenerative diseases
DALTON TRANSACTIONS, 42, 6058-6073 2013
Andreia Nunes , Sergio M. Marques , Catarina Quintanova , Diana F. Silva , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Hydroxypyri(mi)dine-Based Chelators as Antidotes of Toxicity Due to Aluminum and Actinides
CURRENT MEDICINAL CHEMISTRY, 19, 2773-2793 6 2012
M. Amélia Santos , M. Alexandra Esteves , Sílvia Chaves

Hydroxypyridinones as privileged chelating structures for the design of medicinal drugs
COORDINATION CHEMISTRY REVIEWS, 256, 240-259 1 2012
M. Amélia Santos , Sergio M. Marques , Sílvia Chaves

Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: Physico-chemical properties and anti-oxidant activity
JOURNAL OF INORGANIC BIOCHEMISTRY, 114, 38-46 9 2012
Sílvia Chaves , Sonia Canario , Marta P. Carrasco , Lurdes Mira , M. Amélia Santos

A gallium complex with a new tripodal tris-hydroxypyridinone for potential nuclear diagnostic imaging solution and in vivo studies of Ga-67-labeled species
JOURNAL OF INORGANIC BIOCHEMISTRY, 105, 31-38 1 2011
Sílvia Chaves , Ana C. Mendonca , Sergio M. Marques , M. Isabel Prata , Ana C. Santos , Andre F. Martins , Carlos F. G. C. Geraldes , M. Amélia Santos

New Tris(hydroxypyridinones) as Iron and Aluminium Sequestering Agents: Synthesis, Complexation and In Vivo Studies
CHEMISTRY-A EUROPEAN JOURNAL, 16, 10535-10545 2010
Sílvia Chaves , Sergio M. Marques , Andre M. F. Matos , Andreia Nunes , Lurdes Gano , Tiziano Tuccinardi , Adriano Martinelli , M. Amélia Santos

Complexes of hydroxy(thio)pyrone and hydroxy(thio)pyridinone with Zn(II) and Mo(VI). Thermodynamic stability and insulin-mimetic activity
METALLOMICS, 2, 220-227 2010
Sílvia Chaves , Ratomir Jelic , Catarina Mendonca , Marta P. Carrasco , Yutaka Yoshikawa , Hiromu Sakurai , M. Amélia Santos

Combined chelation based on glycosyl-mono- and bis-hydroxypyridinones for aluminium mobilization: Solution and biodistribution studies
JOURNAL OF INORGANIC BIOCHEMISTRY, 103, 1521-1529 11 2009
Sílvia Chaves , Paul I. Dron , Florina A. Danalache , Diana Sacoto , Lurdes Gano , M. Amélia Santos