Gd-III and Ga-III complexes with a new tris-3,4-HOPO ligand as new imaging probes: complex stability, magnetic properties and biodistribution
DALTON TRANSACTIONS, 51, 6436-6447 2022
Sílvia Chaves , Karolina Gwizdala , Karam Chand , Lurdes Gano , Agnes Pallier , Eva Toth , M. Amélia Santos

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms
MOLECULES, 27, 2022
M. Amélia Santos , Anna Irto , Peter Buglyo , Sílvia Chaves

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer s Disease
ANTIOXIDANTS, 11, 2022
Alessia Carocci , Alexia Barbarossa , Rosalba Leuci , Antonio Carrieri , Leonardo Brunetti , Antonio Laghezza , Marco Catto , Francesco Limongelli , Sílvia Chaves , Paolo Tortorella , Cosimo Damiano Altomare , M. Amélia Santos , Fulvio Loiodice , Luca Piemontese

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer s Disease
BIOMEDICINES, 10, 2022
David Vicente-Zurdo , Noelia Rosales-Conrado , M. Eugenia Leon-Gonzalez , Leonardo Brunetti , Luca Piemontese , M. Amélia Santos , Sandra M. Cardoso , Yolanda Madrid , Sílvia Chaves

Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer s Agents
CHEMISTRY \& BIODIVERSITY, 18, 2 2021
Asha Hiremathad , Sílvia Chaves , Rangappa S. Keri

Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer s Disease
MOLECULES, 26, 3 2021
Fausto Queda , Sonia Calo , Karolina Gwizdala , Joao D. Magalhaes , Sandra M. Cardoso , Sílvia Chaves , Luca Piemontese , M. Amélia Santos

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer s Disease Agents
BIOMOLECULES, 11, 1 2021
Viviana Poliseno , Sílvia Chaves , Leonardo Brunetti , Fulvio Loiodice , Antonio Carrieri , Antonio Laghezza , Paolo Tortorella , Joao D. Magalhaes , Sandra M. Cardoso , M. Amélia Santos , Luca Piemontese

Multifunctional Small Molecules as Potential Anti-Alzheimer s Disease Agents
MOLECULES, 26, 2021
Beatrice Bargagna , Lidia Ciccone , Susanna Nencetti , M. Amélia Santos , Sílvia Chaves , Caterina Camodeca , Elisabetta Orlandini

Recent Multi-target Approaches on the Development of Anti- Alzheimer s Agents Integrating Metal Chelation Activity
CURRENT MEDICINAL CHEMISTRY, 28, 7247-7277 2021
Sílvia Chaves , Katalin Varnagy , M. Amélia Santos

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer s Disease
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35, 211-226 1 2020
Gaia Fancellu , Karam Chand , Daniel Tomás , Elisabetta Orlandini , Luca Piemontese , Diana F. Silva , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Donepezil-based hybrids as multifunctional anti-Alzheimer s disease chelating agents: Effect of positional isomerization
JOURNAL OF INORGANIC BIOCHEMISTRY, 206, 5 2020
Marina Costa , Romane Josselin , Diana F. Silva , Sandra M. Cardoso , V May , Sílvia Chaves , M. Amélia Santos

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer s Disease
MOLECULES, 25, 2 2020
Sílvia Chaves , Simonetta Resta , Federica Rinaldo , Marina Costa , Romane Josselin , Karolina Gwizdala , Luca Piemontese , Vito Capriati , M. Amélia Santos , Sandra M. Cardoso

New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation
DALTON TRANSACTIONS, 48, 16167-16183 11 2019
Valeria M. Nurchi , Rosita Cappai , Karam Chand , Sílvia Chaves , Lurdes Gano , G. Crisponi , M. Peana , M. Antonietta Zoroddu , M. Amélia Santos

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer s Disease
MOLECULES, 24, 2 2019
Rajeshwari Rajeshwari , Karam Chand , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update
CURRENT MEDICINAL CHEMISTRY, 25, 97-112 2018
Sílvia Chaves , Luca Piemontese , Asha Hiremathad , Maria A. Santos

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer s disease therapy
JOURNAL OF INORGANIC BIOCHEMISTRY, 179, 82-96 2 2018
Asha Hiremathad , Karam Chand , Lori Tolayan , Rajeshwari , Rangappa S. Keri , A. Raquel Esteves , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies
JOURNAL OF MEDICINAL CHEMISTRY, 61, 4421-4435 5 2018
Elisa Nuti , Doretta Cuffaro , Elisa Bernardini , Caterina Camodeca , Laura Panelli , Sílvia Chaves , Lidia Ciccone , Livia Tepshi , Laura Vera , Elisabetta Orlandini , Susanna Nencetti , Enrico A. Stura , M. Amélia Santos , Vincent Dive , Armando Rossello

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer s disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 148, 255-267 3 2018
Asha Hiremathad , Rangappa S. Keri , A. Raquel Esteves , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer s agents
NEW JOURNAL OF CHEMISTRY, 42, 16503-16515 10 2018
Sílvia Chaves , Asha Hiremathad , Daniel Tomás , Rangappa S. Keri , Luca Piemontese , M. Amélia Santos

Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer s disease: a two-in-one drug
METALLOMICS, 10, 1460-1475 10 2018
Karam Chand , Rajeshwari , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos