Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer s Disease
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35, 211-226 1 2020
Gaia Fancellu , Karam Chand , Daniel Tomás , Elisabetta Orlandini , Luca Piemontese , Diana F. Silva , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Donepezil-based hybrids as multifunctional anti-Alzheimer s disease chelating agents: Effect of positional isomerization
JOURNAL OF INORGANIC BIOCHEMISTRY, 206, 5 2020
Marina Costa , Romane Josselin , Diana F. Silva , Sandra M. Cardoso , V May , Sílvia Chaves , M. Amélia Santos

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer s Disease
MOLECULES, 25, 2 2020
Sílvia Chaves , Simonetta Resta , Federica Rinaldo , Marina Costa , Romane Josselin , Karolina Gwizdala , Luca Piemontese , Vito Capriati , M. Amélia Santos , Sandra M. Cardoso

New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation
DALTON TRANSACTIONS, 48, 16167-16183 11 2019
Valeria M. Nurchi , Rosita Cappai , Karam Chand , Sílvia Chaves , Lurdes Gano , G. Crisponi , M. Peana , M. Antonietta Zoroddu , M. Amélia Santos

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer s Disease
MOLECULES, 24, 2 2019
Rajeshwari Rajeshwari , Karam Chand , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update
CURRENT MEDICINAL CHEMISTRY, 25, 97-112 2018
Sílvia Chaves , Luca Piemontese , Asha Hiremathad , Maria A. Santos

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer s disease therapy
JOURNAL OF INORGANIC BIOCHEMISTRY, 179, 82-96 2 2018
Asha Hiremathad , Karam Chand , Lori Tolayan , Rajeshwari , Rangappa S. Keri , A. Raquel Esteves , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies
JOURNAL OF MEDICINAL CHEMISTRY, 61, 4421-4435 5 2018
Elisa Nuti , Doretta Cuffaro , Elisa Bernardini , Caterina Camodeca , Laura Panelli , Sílvia Chaves , Lidia Ciccone , Livia Tepshi , Laura Vera , Elisabetta Orlandini , Susanna Nencetti , Enrico A. Stura , M. Amélia Santos , Vincent Dive , Armando Rossello

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer s disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 148, 255-267 3 2018
Asha Hiremathad , Rangappa S. Keri , A. Raquel Esteves , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer s agents
NEW JOURNAL OF CHEMISTRY, 42, 16503-16515 10 2018
Sílvia Chaves , Asha Hiremathad , Daniel Tomás , Rangappa S. Keri , Luca Piemontese , M. Amélia Santos

Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer s disease: a two-in-one drug
METALLOMICS, 10, 1460-1475 10 2018
Karam Chand , Rajeshwari , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer s drug candidates
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 33, 1212-1224 8 2018
Luca Piemontese , Daniel Tomás , Asha Hiremathad , Vito Capriati , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies
NEW JOURNAL OF CHEMISTRY, 42, 8050-8061 5 2018
Rosita Cappai , Karam Chand , Joanna I. Lachowicz , Sílvia Chaves , Lurdes Gano , G. Crisponi , V. M. Nurchi , M. Peana , Maria Antonietta Zoroddu , M. Amélia Santos

Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer s drug candidates
RSC ADVANCES, 6, 53519-53532 2016
Asha Hiremathad , Karam Chand , A. Raquel Esteves , Sandra M. Cardoso , Rona R. Ramsay , Sílvia Chaves , Rangappa S. Keri , M. Amélia Santos

New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer s Disease
CHEMICAL BIOLOGY \& DRUG DESIGN, 87, 101-111 1 2016
Rangappa S. Keri , Catarina Quintanova , Sílvia Chaves , Diana F. Silva , Sandra M. Cardoso , M. Amélia Santos

Recent progress in repositioning Alzheimer s disease drugs based on a multitarget strategy
FUTURE MEDICINAL CHEMISTRY, 8, 2113-2142 11 2016
M. Amélia Santos , Karam Chand , Sílvia Chaves

Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer s agents: AChE inhibition, antioxidant activity and metal chelating capacity
JOURNAL OF INORGANIC BIOCHEMISTRY, 163, 266-277 10 2016
Karam Chand , Hesham M. Alsoghier , Sílvia Chaves , M. Amélia Santos

Recent progress in multifunctional metal chelators as potential drugs for Alzheimer s disease
COORDINATION CHEMISTRY REVIEWS, 327, 287-303 11 2016
M. Amélia Santos , Karam Chand , Sílvia Chaves

Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles
JOURNAL OF INORGANIC BIOCHEMISTRY, 151, 58-66 10 2015
Catarina Quintanova , Rangappa S. Keri , Sílvia Chaves , M. Amélia Santos

3-hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use
FUTURE MEDICINAL CHEMISTRY, 7, 383-410 2015
M. Amélia Santos , Sílvia Chaves