A Multi-Technique Investigation of the Complex Formation Equilibria between Bis-Deferiprone Derivatives and Oxidovanadium (IV)
MOLECULES, 27, 2022
Rosita Cappai , Alessandra Fantasia , G. Crisponi , Eugenio Garribba , M. Amélia Santos , Valeria Marina Nurchi

Gd-III and Ga-III complexes with a new tris-3,4-HOPO ligand as new imaging probes: complex stability, magnetic properties and biodistribution
DALTON TRANSACTIONS, 51, 6436-6447 2022
Sílvia Chaves , Karolina Gwizdala , Karam Chand , Lurdes Gano , Agnes Pallier , Eva Toth , M. Amélia Santos

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms
MOLECULES, 27, 2022
M. Amélia Santos , Anna Irto , Peter Buglyo , Sílvia Chaves

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer s Disease
ANTIOXIDANTS, 11, 2022
Alessia Carocci , Alexia Barbarossa , Rosalba Leuci , Antonio Carrieri , Leonardo Brunetti , Antonio Laghezza , Marco Catto , Francesco Limongelli , Sílvia Chaves , Paolo Tortorella , Cosimo Damiano Altomare , M. Amélia Santos , Fulvio Loiodice , Luca Piemontese

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer s Disease
BIOMEDICINES, 10, 2022
David Vicente-Zurdo , Noelia Rosales-Conrado , M. Eugenia Leon-Gonzalez , Leonardo Brunetti , Luca Piemontese , M. Amélia Santos , Sandra M. Cardoso , Yolanda Madrid , Sílvia Chaves

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer s Disease
BIOMEDICINES, 10, 2022
David Vicente-Zurdo , Noelia Rosales-Conrado , M. Eugenia Leon-Gonzalez , Leonardo Brunetti , Luca Piemontese , M. Amélia Santos , Sandra M. Cardoso , Yolanda Madrid , Sílvia Chaves

Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer s Disease
MOLECULES, 26, 3 2021
Fausto Queda , Sonia Calo , Karolina Gwizdala , Joao D. Magalhaes , Sandra M. Cardoso , Sílvia Chaves , Luca Piemontese , M. Amélia Santos

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer s Disease Agents
BIOMOLECULES, 11, 1 2021
Viviana Poliseno , Sílvia Chaves , Leonardo Brunetti , Fulvio Loiodice , Antonio Carrieri , Antonio Laghezza , Paolo Tortorella , Joao D. Magalhaes , Sandra M. Cardoso , M. Amélia Santos , Luca Piemontese

Bifunctional 3-Hydroxy-4-Pyridinones as Potential Selective Iron(III) Chelators: Solution Studies and Comparison with Other Metals of Biological and Environmental Relevance
MOLECULES, 26, 2021
Anna Irto , Paola Cardiano , Karam Chand , Rosalia Maria Cigala , Francesco Crea , Concetta De Stefano , M. Amélia Santos

Multifunctional Small Molecules as Potential Anti-Alzheimer s Disease Agents
MOLECULES, 26, 2021
Beatrice Bargagna , Lidia Ciccone , Susanna Nencetti , M. Amélia Santos , Sílvia Chaves , Caterina Camodeca , Elisabetta Orlandini

Recent Multi-target Approaches on the Development of Anti- Alzheimer s Agents Integrating Metal Chelation Activity
CURRENT MEDICINAL CHEMISTRY, 28, 7247-7277 2021
Sílvia Chaves , Katalin Varnagy , M. Amélia Santos

Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-Based Scaffolds en Route to Donepezil-Like Compounds
MOLECULES, 25, 2 2020
Luca Piemontese , Roberta Sergio , Federica Rinaldo , Leonardo Brunetti , Filippo Maria Perna , M. Amélia Santos , Vito Capriati

DFO@EVOH and 3,4-HP@EVOH: Towards New Polymeric Sorbents for Iron(III)
CHEMOSENSORS, 8, 12 2020
Giancarla Alberti , Camilla Zanoni , Lisa Rita Magnaghi , M. Amélia Santos , V. M. Nurchi , Raffaela Biesuz

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer s Disease
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35, 211-226 1 2020
Gaia Fancellu , Karam Chand , Daniel Tomás , Elisabetta Orlandini , Luca Piemontese , Diana F. Silva , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Donepezil-based hybrids as multifunctional anti-Alzheimer s disease chelating agents: Effect of positional isomerization
JOURNAL OF INORGANIC BIOCHEMISTRY, 206, 5 2020
Marina Costa , Romane Josselin , Diana F. Silva , Sandra M. Cardoso , V May , Sílvia Chaves , M. Amélia Santos

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer s Disease
MOLECULES, 25, 2 2020
Sílvia Chaves , Simonetta Resta , Federica Rinaldo , Marina Costa , Romane Josselin , Karolina Gwizdala , Luca Piemontese , Vito Capriati , M. Amélia Santos , Sandra M. Cardoso

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer s Disease
MOLECULES, 25, 2 2020
Sílvia Chaves , Simonetta Resta , Federica Rinaldo , Marina Costa , Romane Josselin , Karolina Gwizdala , Luca Piemontese , Vito Capriati , M. Amélia Santos , Sandra M. Cardoso

Complexation of environmentally and biologically relevant metals with bifunctional 3-hydroxy-4-pyridinones
JOURNAL OF MOLECULAR LIQUIDS, 319, 12 2020
Anna Irto , Paola Cardiano , Karam Chand , Rosalia Maria Cigala , Francesco Crea , Concetta De Stefano , Giuseppe Gattuso , Silvio Sammartano , M. Amélia Santos

New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation
DALTON TRANSACTIONS, 48, 16167-16183 11 2019
Valeria M. Nurchi , Rosita Cappai , Karam Chand , Sílvia Chaves , Lurdes Gano , G. Crisponi , M. Peana , M. Antonietta Zoroddu , M. Amélia Santos

A new bis-(3-hydroxy-4-pyridinone)-DTPA-derivative: Synthesis, complexation of di-/tri-valent metal cations and in vivo M3+ sequestering ability
JOURNAL OF MOLECULAR LIQUIDS, 281, 280-294 5 2019
Anna Irto , Paola Cardiano , Karam Chand , Rosalia Maria Cigala , Francesco Crea , Concetta De Stefano , Lurdes Gano , Giuseppe Gattuso , Silvio Sammartano , M. Amélia Santos