Publications

Journal Article

Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-Based Scaffolds en Route to Donepezil-Like Compounds
MOLECULES, 25, 2 2020
Luca Piemontese , Roberta Sergio , Federica Rinaldo , Leonardo Brunetti , Filippo Maria Perna , M. Amélia Santos , Vito Capriati

Novel tacrine-benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer s Disease
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35, 211-226 1 2020
Gaia Fancellu , Karam Chand , Daniel Tomás , Elisabetta Orlandini , Luca Piemontese , Diana F. Silva , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Donepezil-based hybrids as multifunctional anti-Alzheimer s disease chelating agents: Effect of positional isomerization
JOURNAL OF INORGANIC BIOCHEMISTRY, 206, 5 2020
Marina Costa , Romane Josselin , Diana F. Silva , Sandra M. Cardoso , V May , Sílvia Chaves , M. Amélia Santos

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer s Disease
MOLECULES, 25, 2 2020
Sílvia Chaves , Simonetta Resta , Federica Rinaldo , Marina Costa , Romane Josselin , Karolina Gwizdala , Luca Piemontese , Vito Capriati , M. Amélia Santos , Sandra M. Cardoso

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer s Disease
MOLECULES, 25, 2 2020
Sílvia Chaves , Simonetta Resta , Federica Rinaldo , Marina Costa , Romane Josselin , Karolina Gwizdala , Luca Piemontese , Vito Capriati , M. Amélia Santos , Sandra M. Cardoso

Complexation of environmentally and biologically relevant metals with bifunctional 3-hydroxy-4-pyridinones
JOURNAL OF MOLECULAR LIQUIDS, 319, 12 2020
Anna Irto , Paola Cardiano , Karam Chand , Rosalia Maria Cigala , Francesco Crea , Concetta De Stefano , Giuseppe Gattuso , Silvio Sammartano , M. Amélia Santos

New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation
DALTON TRANSACTIONS, 48, 16167-16183 11 2019
Valeria M. Nurchi , Rosita Cappai , Karam Chand , Sílvia Chaves , Lurdes Gano , G. Crisponi , M. Peana , M. Antonietta Zoroddu , M. Amélia Santos

A new bis-(3-hydroxy-4-pyridinone)-DTPA-derivative: Synthesis, complexation of di-/tri-valent metal cations and in vivo M3+ sequestering ability
JOURNAL OF MOLECULAR LIQUIDS, 281, 280-294 5 2019
Anna Irto , Paola Cardiano , Karam Chand , Rosalia Maria Cigala , Francesco Crea , Concetta De Stefano , Lurdes Gano , Giuseppe Gattuso , Silvio Sammartano , M. Amélia Santos

A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe3+, Al3+, Cu2+ and Zn2+, and in vivo bioassays
JOURNAL OF INORGANIC BIOCHEMISTRY, 193, 152-165 4 2019
Valeria M. Nurchi , Maria de Guadalupe Jaraquemada-Pelaez , G. Crisponi , J. I. Lachowicz , Rosita Cappai , Lurdes Gano , M. Amélia Santos , Andrea Melchior , Marilena Tolazzi , M. Peana , Serenella Medici , Maria Antonietta Zoroddu

NMR spectroscopic, linear and non-linear optical properties of 1,3-benzothiazol-2-yl-(phenylhydrazono)acetonitrile (BTPA) azo dye
JOURNAL OF MOLECULAR STRUCTURE, 1179, 315-324 3 2019
H. M. Alsoghier , M. A. Selim , H. M. A. Salman , H. M. Rageh , M. Amélia Santos , S. A. Ibrahim , M. Dongol , T. Soga , A. A. Abuelwafa

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer s Disease
MOLECULES, 24, 2 2019
Rajeshwari Rajeshwari , Karam Chand , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Speciation Studies of Bifunctional 3-Hydroxy-4-Pyridinone Ligands in the Presence of Zn2+ at Different Ionic Strengths and Temperatures
MOLECULES, 24, 11 2019
Anna Irto , Paola Cardiano , Salvatore Cataldo , Karam Chand , Rosalia Maria Cigala , Francesco Crea , Concetta De Stefano , Giuseppe Gattuso , Nicola Muratore , Alberto Pettignano , Silvio Sammartano , M. Amélia Santos

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer s disease therapy
JOURNAL OF INORGANIC BIOCHEMISTRY, 179, 82-96 2 2018
Asha Hiremathad , Karam Chand , Lori Tolayan , Rajeshwari , Rangappa S. Keri , A. Raquel Esteves , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies
JOURNAL OF MEDICINAL CHEMISTRY, 61, 4421-4435 5 2018
Elisa Nuti , Doretta Cuffaro , Elisa Bernardini , Caterina Camodeca , Laura Panelli , Sílvia Chaves , Lidia Ciccone , Livia Tepshi , Laura Vera , Elisabetta Orlandini , Susanna Nencetti , Enrico A. Stura , M. Amélia Santos , Vincent Dive , Armando Rossello

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer s disease
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 148, 255-267 3 2018
Asha Hiremathad , Rangappa S. Keri , A. Raquel Esteves , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer s agents
NEW JOURNAL OF CHEMISTRY, 42, 16503-16515 10 2018
Sílvia Chaves , Asha Hiremathad , Daniel Tomás , Rangappa S. Keri , Luca Piemontese , M. Amélia Santos

Tacrine-deferiprone hybrids as multi-target-directed metal chelators against Alzheimer s disease: a two-in-one drug
METALLOMICS, 10, 1460-1475 10 2018
Karam Chand , Rajeshwari , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Development of a sensor for trivalent iron: AHP fixed on mesoporous silica
NEW JOURNAL OF CHEMISTRY, 42, 15237-15244 9 2018
Raffaela Biesuz , M. Amélia Santos , V. M. Nurchi , Giancarla Alberti

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer s drug candidates
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 33, 1212-1224 8 2018
Luca Piemontese , Daniel Tomás , Asha Hiremathad , Vito Capriati , Emanuel Candeias , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: synthesis, complexation and in vivo studies
NEW JOURNAL OF CHEMISTRY, 42, 8050-8061 5 2018
Rosita Cappai , Karam Chand , Joanna I. Lachowicz , Sílvia Chaves , Lurdes Gano , G. Crisponi , V. M. Nurchi , M. Peana , Maria Antonietta Zoroddu , M. Amélia Santos

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