Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study
ARCHIVES OF TOXICOLOGY, 91, 1199-1211 3 2017
Pedro F. Pinheiro , Sofia A. Pereira , Shrika G. Harjivan , Inês Sofia Lança Martins , Aline T. Marinho , Madalena Cipriano , Cristina C. Jacob , Nuno G. Oliveira , Matilde F. Castro , M. Matilde Marques , Alexandra Maria Moita Antunes , Joana P. Miranda

Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 105, 47-54 7 2017
Nadia M. Grilo , M. Joao Correia , Joana P. Miranda , Madalena Cipriano , Jacinta Serpa , M. Matilde Marques , Emilia C. Monteiro , Alexandra Maria Moita Antunes , Lucilia N. Diogo , Sofia A. Pereira

Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study
FOOD AND CHEMICAL TOXICOLOGY, 99, 170-181 1 2017
Linda S. Von Tungeln , Nigel J. Walker , Greg R. Olson , Maria C. B. Mendoza , Robert P. Felton , Brett T. Thorn , M. Matilde Marques , Igor P. Pogribny , Daniel R. Doerge , Frederick A. Beland

Toxic events induced by the antiepileptic drug carbamazepine: Is bioactivation really involved?
TOXICOLOGY LETTERS, 280, S241 10 2017
Alexandra M. M. Antunes , Ines L. Martins , J. Paulo Telo , M. Matilde Marques

3D in vitro cultures of human hepatocyte-like cells as an alternative competent model for nevirapine biotransformation studies
TOXICOLOGY LETTERS, 280, S263 10 2017
Madalena Cipriano , Pedro F. Pinheiro , Catarina Sequeira , Jorge M. Santos , Nuno G. Oliveira , Alexandra M. M. Antunes , M. Matilde Marques , Joana S. Rodrigues , Matilde Castro , Sofia A. Pereira , Joana P. Miranda

New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan
TOXICOLOGY LETTERS, 264, 106-113 12 2016
João Pedro da Costa Nunes , Inês Sofia Lança Martins , Catarina Sofia Romão Charneira , Igor P. Pogribny , Aline de Conti , Frederick A. Beland , M. Matilde Marques , Cristina C. Jacob , Alexandra Maria Moita Antunes

Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients
TOXICOLOGY LETTERS, 260, 28-35 10 2016
Nadia M. Grilo , M. Joao Correia , Catarina Sequeira , Shrika G. Harjivan , Umbelina Caixas , Lucilia N. Diogo , M. Matilde Marques , Emilia C. Monteiro , Alexandra Maria Moita Antunes , Sofia A. Pereira

Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 82, 147-153 1 2016
Aline T. Marinho , Clara G. Dias , Pedro F. Pinheiro , Ana Rita Lemos , Alexandra Maria Moita Antunes , M. Matilde Marques , Emlia C. Monteiro , Joana P. Miranda , Sofia A. Pereira

Metabolic activation of the nevirapine metabolite 12-hydroxy-nevirapine to 12-formylnevirapine - A possible factor in nevirapine toxicity
TOXICOLOGY LETTERS, 238, S360-S361 10 2015
A. Godinho , G. Surratt , G. Gamboa da Costa , F. A. Beland , Alexandra Maria Moita Antunes , M. Matilde Marques

Activation of aloe-emodin to biologically plausible electrophiles - Possible role in the carcinogenicity of aloe vera whole leaf extracts
TOXICOLOGY LETTERS, 238, S359 10 2015
Mohamed Y. Mahgoub , L. Cavaca , F. A. Beland , M. Matilde Marques

Protein adducts from carbamazepine-10,11-epoxide, the major metabolite of the antiepileptic drug carbamazepine: possible biomarkers of toxicity
TOXICOLOGY LETTERS, 238, S359 10 2015
Inês Sofia Lança Martins , M. Matilde Marques , Alexandra Maria Moita Antunes

Effect of substituents in the molecular and supramolecular architectures of 1-ferrocenyl-2(aryl) thioethanones
CRYSTENGCOMM, 17, 3089-3102 2015
João Ferreira da Silva , Shrika G. Harjivan , Andre P. Ferreira , Karina Shimizu , M. Matilde Marques , M. Teresa Duarte

Carcinogenicity of glycidamide in B6C3F(1) mice and F344/N rats from a two-year drinking water exposure
FOOD AND CHEMICAL TOXICOLOGY, 86, 104-115 12 2015
Frederick A. Beland , Greg R. Olson , Maria C. B. Mendoza , M. Matilde Marques , Daniel R. Doerge

Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats
CHEMICO-BIOLOGICAL INTERACTIONS, 233, 115-121 5 2015
Pedro F. Pinheiro , A. T. Marinho , Alexandra Maria Moita Antunes , M. Matilde Marques , S. A. Pereira , Joana P. Miranda

Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts
TOXICOLOGY RESEARCH, 4, 1565-1577 2015
Shrika G. Harjivan , Pedro F. Pinheiro , Inês Sofia Lança Martins , Ana L. Godinho , Riccardo Wanke , P P Santos , Sofia A. Pereira , Frederick A. Beland , M. Matilde Marques , Alexandra Maria Moita Antunes

ANTI-HISTONE ANTIBODIES IN HIV-INFECTED PATIENTS ON NEVIRAPINE-CONTAINING ANTIRETROVIRAL THERAPY
CLINICAL THERAPEUTICS, 37, E142 8 2015
S. A. Pereira , Alexandra Maria Moita Antunes , C. G. Dias , A. T. Marinho , S. G. Harjivan , M. Fonseca , S. Maia , T. Branco , U. Caixas , M. Matilde Marques , E. C. Monteiro

First in vitro evidence for a catechol metabolite from the anti-HIV drug efavirenz - A plausible role in toxicity
TOXICOLOGY LETTERS, 238, S360 10 2015
S. G. Harjivan , R. Wanke , K. Woodling , G. Gamboa da Costa , F. A. Beland , Alexandra Maria Moita Antunes , M. Matilde Marques

Enzymatic bioactivation of the phenolic nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine to quinoid intermediates: Covalent adduct formation with nitrogen-based amino acids
TOXICOLOGY LETTERS, 238, S359-S360 10 2015
S. G. Harjivan , Pedro F. Pinheiro , Inês Sofia Lança Martins , D. A. Novais , R. Wanke , P P Santos , S. A. Pereira , F. A. Beland , M. Matilde Marques , Alexandra Maria Moita Antunes

Thiol status in HIV-infected patients: The effect of nevirapine metabolism
TOXICOLOGY LETTERS, 229, S95 9 2014
Clara G. Dias , Aline T. Marinho , Umbelina Caixas , Ines Faustino , Alexandra Maria Moita Antunes , M. Matilde Marques , Emilia C. Monteiro , Sofia A. Pereira

An animal model to explore efavirenz toxicokinetics and its relation to neurological phenotype
TOXICOLOGY LETTERS, 229, S244 9 2014
Nadia M. Grilo , Vania L. Batalha , Luisa V. Lopes , M. Matilde Marques , Emilia C. Monteiro , Alexandra Maria Moita Antunes , Sofia A. Pereira