Publication Type Journal Article
Title Core-shell polycationic polyurea pharmadendrimers: new-generation of sustainable broad-spectrum antibiotics and antifungals
Authors Sandra N. Pinto Dalila Mil-Homens Rita F. Pires Marta M. Alves Gabriel Serafim Nuno Martinho Manuel Melo Arsenio M. Fialho Vasco D. B. Bonifacio
Groups CSSE
Journal BIOMATERIALS SCIENCE
Year 2022
Month
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Volume 10
Number 18
Pages 5197-5207
Abstract The efficacy of conventional antimicrobials is falling to critical levels and raising alarming concerns around the globe. In this scenery, engineered nanoparticles emerged as a solid strategy to fight growing deadly infections. Here, we show the in vitro and in vivo performance of pharmadendrimers, a novel class of engineered polyurea dendrimers that are synthetic mimics of antibacterial peptides, against a collection of both Gram-positive and Gram-negative bacteria and fungi. These nanobiomaterials are stable solids prepared by low-cost and green processes, display a dense positively charged core-shell, and are biocompatible and hemocompatible drugs. Mechanistic data, corroborated by coarse-grained molecular dynamics simulations, points towards a fast-killing mechanism via membrane disruption, triggered by electrostatic interactions. Altogether this study provides strong evidence and support for the future use of polyurea pharmadendrimers in antibacterial and antifungal nanotherapeutics.
DOI http://dx.doi.org/10.1039/d2bm00679k
ISBN
Publisher ROYAL SOC CHEMISTRY
Book Title
ISSN 2047-4830
EISSN 2047-4849
Conference Name
Bibtex ID WOS:000830097800001
Observations
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