| Publication Type |
Journal Article |
| Title |
TSDC and DSC Investigation on the Molecular Mobility in the Amorphous Solid State and in the Glass Transformation Region of Two Benzodiazepine Derivatives: Diazepam and Nordazepam |
| Authors |
H. P. Diogo J. J. Moura-Ramos |
| Groups |
BioMol |
| Journal |
JOURNAL OF PHARMACEUTICAL SCIENCES |
| Year |
2022 |
| Month |
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|
| Volume |
111 |
| Number |
8 |
| Pages |
2239-2248 |
| Abstract |
In this work we study the molecular mobility in the amorphous solid state and in the glass transformation region of two compounds, diazepam and nordazepam; these are two benzodiazepines, a family of psychotropic drugs with sedative, anxiolytic and muscle-relaxing properties. The experimental techniques used are thermostimulated currents (TSC) and differential scanning calorimetry (DSC). TSC is a time-dependent technique recognized for its high resolving power; the use of this technique in the depolarization and polarization modes (TSDC and TSPC respectively), provides results that confirm and complement results of dielectric relaxation spectroscopy (DRS) published recently. On the other hand, the variation with the heating rate of the temperature position of the DSC glass transition signal also allowed the estimation of the activation energy at T(g )and of the dynamic fragility of the two glass formers. (C) 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved. |
| DOI |
http://dx.doi.org/10.1016/j.xphs.2022.02.010 |
| ISBN |
|
| Publisher |
ELSEVIER SCIENCE INC |
| Book Title |
|
| ISSN |
0022-3549 |
| EISSN |
1520-6017 |
| Conference Name |
|
| Bibtex ID |
WOS:000829687700012 |
| Observations |
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