Publication Type Journal Article
Title Recognition and mechanistic investigation of anion sensing by ruthenium(ii) arene complexes and bio-imaging application
Authors Chanchal Sonkar Sayantan Sarkar Novina Malviya Maxim L. Kuznetsov Suman Mukhopadhyay
Groups CCC
Journal DALTON TRANSACTIONS
Year 2022
Month
Notice: Undefined index: in /afs/ist.utl.pt/groups/cqe/web/tmp/templates_c/77f86a5f762542dadf50c7f7fefa96acd45c2726_0.file.paper.tpl.html.php on line 163
Volume 51
Number 34
Pages 13071-13084
Abstract In this work, four new ruthenium complexes [Ru(eta(6)-p-cymene)(L1)Cl] 1, [Ru(eta(6)-p-cymene)(L2)Cl] 2, [Ru(eta(6)-p-cymene)(L3)Cl] 3 and [Ru(eta(6)-p-cymene)(L4)Cl] 4 [HL1 = (2-cyanophenyl)glycine; HL2 = (5-chloro-2-cyanophenyl)glycine; HL3 = (2-cyano-3-fluorophenyl)glycine; HL4 = (4-cyanophenyl)glycine] were synthesized and well characterized by several spectroscopic and analytical techniques. Complexes 1 and 3 were found to be fluorescent in most of the solvents; however, 2 and 4 were found to be fluorescent mostly in EtOAc, DMF and ethanol. Amongst these four complexes, 3 has shown selective sensing against CO32- and SO42- anions by quenching of fluorescence. The LOD values are found to be in the sub-micromolar range. Investigations of the sensing mechanism performed by computation and NMR studies indicate a possible adduct formation between the NH group of the ligand and the anion(s) through hydrogen bond formation, which ultimately might lead to proton transfer to the bi-negative anion. The quantum yield of the complex 3 was found to decrease on addition of CO32- and SO42- anions from 0.46 to 0.13 and 0.12, respectively. The Job s plot indicates the binding between the probe and anion in a 1 : 1 ratio for both CO32- and SO42- anions. Along with that, all the complexes were found to be biocompatible when tested against several cell lines showing very high IC50 values. It can also be observed that 1 is capable of penetrating within the cells and can act as a cell imaging agent showing fluorescence, and thus can be used for bio-imaging purposes.
DOI http://dx.doi.org/10.1039/d2dt01726a
ISBN
Publisher ROYAL SOC CHEMISTRY
Book Title
ISSN 1477-9226
EISSN 1477-9234
Conference Name
Bibtex ID WOS:000840924800001
Observations
Back to Publications List