Publication Type Journal Article
Title Cyclam-based iron(iii) and copper(ii) complexes: synthesis, characterization and application as antifungal agents
Authors Stephanie Almada Luisa B. Maia Joao C. Waerenborgh Bruno J. C. Vieira Nuno P. Mira Elisabete R. Silva Fatima Cerqueira Eugenia Pinto Luis G. Alves
Groups BIOIN
Journal NEW JOURNAL OF CHEMISTRY
Year 2022
Month
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Volume 46
Number 35
Pages 16764-16770
Abstract New cyclam-based complexes of formulae [\H-2(4-CF3PhCH2)(2)Cyclam\FeCl2]Cl and [\H-2(4-CF3PhCH2)(2)Cyclam\Cu](CH3COO)(2)center dot 2H(2)O were synthesized, in very high yields, by the reaction of H-2(4-CF3PhCH2)(2)Cyclam with the corresponding metal salts in methanol. [\H-2(4-CF3PhCH2)(2)Cyclam\FeCl2]Cl was also prepared, quantitatively, in the solid state by mechanochemistry. The Mossbauer spectra of [\H-2(4-CF3PhCH2)(2)Cyclam\FeCl2]Cl show that the high-spin cis complex is the major product of both reactions. The EPR data of [\H-2(4-CF3PhCH2)(2)Cyclam\Cu](CH3COO)(2)center dot 2H(2)O are consistent with two distinct Cu2+ species, whose solid state molecular structures were determined by single crystal X-ray diffraction and correspond to complexes displaying octahedral and square-pyramidal geometries. The screening of the antifungal activity of both metal complexes revealed the higher activity of [\H-2(4-CF3PhCH2)(2)Cyclam\FeCl2]Cl to inhibit the growth of unicellular and multicellular fungal species with described pathogenic potential.
DOI http://dx.doi.org/10.1039/d2nj03161b
ISBN
Publisher ROYAL SOC CHEMISTRY
Book Title
ISSN 1144-0546
EISSN 1369-9261
Conference Name
Bibtex ID WOS:000840917400001
Observations
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