Publication Type |
Journal Article |
Title |
Cyclam-based iron(iii) and copper(ii) complexes: synthesis, characterization and application as antifungal agents |
Authors |
Stephanie Almada Luisa B. Maia Joao C. Waerenborgh Bruno J. C. Vieira Nuno P. Mira Elisabete R. Silva Fatima Cerqueira Eugenia Pinto Luis G. Alves |
Groups |
BIOIN |
Journal |
NEW JOURNAL OF CHEMISTRY |
Year |
2022 |
Month |
Notice: Undefined index: in /afs/ist.utl.pt/groups/cqe/web/tmp/templates_c/77f86a5f762542dadf50c7f7fefa96acd45c2726_0.file.paper.tpl.html.php on line 163
|
Volume |
46 |
Number |
35 |
Pages |
16764-16770 |
Abstract |
New cyclam-based complexes of formulae [\H-2(4-CF3PhCH2)(2)Cyclam\FeCl2]Cl and [\H-2(4-CF3PhCH2)(2)Cyclam\Cu](CH3COO)(2)center dot 2H(2)O were synthesized, in very high yields, by the reaction of H-2(4-CF3PhCH2)(2)Cyclam with the corresponding metal salts in methanol. [\H-2(4-CF3PhCH2)(2)Cyclam\FeCl2]Cl was also prepared, quantitatively, in the solid state by mechanochemistry. The Mossbauer spectra of [\H-2(4-CF3PhCH2)(2)Cyclam\FeCl2]Cl show that the high-spin cis complex is the major product of both reactions. The EPR data of [\H-2(4-CF3PhCH2)(2)Cyclam\Cu](CH3COO)(2)center dot 2H(2)O are consistent with two distinct Cu2+ species, whose solid state molecular structures were determined by single crystal X-ray diffraction and correspond to complexes displaying octahedral and square-pyramidal geometries. The screening of the antifungal activity of both metal complexes revealed the higher activity of [\H-2(4-CF3PhCH2)(2)Cyclam\FeCl2]Cl to inhibit the growth of unicellular and multicellular fungal species with described pathogenic potential. |
DOI |
http://dx.doi.org/10.1039/d2nj03161b |
ISBN |
|
Publisher |
ROYAL SOC CHEMISTRY |
Book Title |
|
ISSN |
1144-0546 |
EISSN |
1369-9261 |
Conference Name |
|
Bibtex ID |
WOS:000840917400001 |
Observations |
|