Publication Type Journal Article
Title Key Parameters on the Antibacterial Activity of Silver Camphor Complexes
Authors Joana P. Costa Silvia A. Sousa Adelino M. Galvão J. Miguel Mata Jorge H. Leitao M Fernanda NN Carvalho
Groups MPPM BIOMOL
Journal ANTIBIOTICS-BASEL
Year 2021
Month February
Volume 10
Number 2
Pages
Abstract Nine new complexes with camphor imine or camphor sulfonimine ligands were synthesized and analytically and spectroscopically characterized, aiming to identify the key parameters that drive the antibacterial activity of the complexes with metal cores and imine substituents with distinct electronic and steric characteristics. The antimicrobial activity of all complexes was evaluated by determining their minimum inhibitory concentrations (MIC) against the Gram-negative Escherichia coli ATCC25922, Pseudomonas aeruginosa 477, and Burkholderia contaminans IST408, and the Gram-positive Staphylococcus aureus Newman. Camphor imine complexes based on the hydroxyl silver center (\Ag(OH)\) typically perform better than those based on the nitrate silver center (\Ag(NO3)\), while ligands prone to establish hydrogen bonding facilitate interactions with the bacterial cell surface structures. A different trend is observed for the silver camphor sulfonimine complexes that are almost non-sensitive to the nature of the metal cores \Ag(OH)\ or \Ag(NO3)\ and display low sensitivity to the Y substituent. The antibacterial activities of the Ag(I) camphor sulfonimine complexes are higher than those of the camphor imine analogues. All the complexes display higher activity towards Gram-negative strains than towards the Gram-positive strain.
DOI http://dx.doi.org/10.3390/antibiotics10020135
ISBN
Publisher
Book Title
ISSN 2079-6382
EISSN
Conference Name
Bibtex ID ISI:000622037100001
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