Publication Type Journal Article
Title Synthesis, characterization, DNA binding ability, in vitro cytotoxicity, electrochemical properties and theoretical studies of copper(II) carboxylate complexes
Authors Maitri Bhattacharjee Smriti Rekha Boruah R. N. Dutta Purkayastha Rakesh Ganguly Debasish Maiti Antonio Franconetti Antonio Frontera A Kirillov Shubhamoy Chowdhury Subhadip Roy Priyatosh Nath
Groups BIOMOL
Journal INORGANICA CHIMICA ACTA
Year 2021
Month April
Volume 518
Number
Pages
Abstract Four copper(II) carboxylate complexes, namely [Cu-2(mu-3,5-dinitrobenzoate-O,O )(4)(4-(dimethylamino)benzaldehyde)(2 )] (1), [Cu-2(mu-benzoate-O,O )(4)(benzoic acid)(2)] (2), [Cu-2(mu-benzoate-O,O )(4)(H2O)(2)] [Cu(benzoate-O, O )(2)(imz)(2)](2H2O)-H-center dot (3) and [Cu(benzoate-O,O )(2)(2-Me-imz)(2)] (4) (imz = imidazole, 2-Me-imz = 2-methyl-imidazole), were synthesized and comprehensively characterized by elemental analysis, spectroscopic methods, single crystal X-ray diffraction, cyclic voltammetry (CV), topological analysis as well as theoretical studies. Single crystal X-ray diffraction revealed that products 1 and 2 are dinuclear paddle-wheel complexes, compound 3 is a co-crystal containing mononuclear and dinuclear blocks, while compound 4 is a mononuclear complex. Hirshfeld surface analysis of the compounds rationalized different types of hydrogen bonds, which also lead to the generation of H-bonded networks in 3 and 4. Their topological analysis disclosed a uninodal 4-connected 2D layer with sql topology in 3 and a uninodal 2-connected 1D chain with 2C1 topology in 4. The interaction of 1-4 with calf thymus DNA was investigated by UV-visible and fluorescence spectroscopy, revealing a moderately strong non-intercalative mode of interaction. In vitro cytotoxicity study of the complexes on HepG2 (human liver hepatocellular carcinoma) cell lines revealed a significant inhibition activity. Electrochemical study of the complexes in CH3CN (1-3) and DMSO (4) solution showed a one electron transfer corresponding to Cu(III)Cu(II)/Cu (II)Cu(II) and Cu(II)Cu(II)/Cu(I)Cu(II) redox couples. The Delta E and I-pa/I-pc values suggest that the redox couples are quasireversible. The DFT study was performed to further rationalize the crystal structures and nuclearity of the obtained copper(II) complexes.
DOI http://dx.doi.org/10.1016/j.ica.2020.120235
ISBN
Publisher
Book Title
ISSN 0020-1693
EISSN 1873-3255
Conference Name
Bibtex ID ISI:000642461200002
Observations
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