Publication Type Journal Article
Title Improved therapeutic nitric oxide delivery by microporous Cu-bearing titanosilicate
Authors Zhi Lin V Pinto Carlos Henriques Fernando Antunes Joao Pires Moises L. Pinto Joao Rocha
Groups CATHPRO
Journal MICROPOROUS AND MESOPOROUS MATERIALS
Year 2021
Month July
Volume 322
Number
Pages
Abstract Copper was incorporated into microporous titanosilicate ETS-4 framework via the in situ hydrothermal synthesis to achieve a more controlled and extended nitric oxide (NO) release profile. Exogeneous delivery of this gasotransmitter may be effective in the therapeutic setting and titanosilicates, in particular ETS-4, has already evidenced its potential as a NO carrier. Copper ions have high affinity for NO coordination and their substitution within the ETS-4 framework was confirmed by energy dispersive X-ray spectrometry (EDS). Samples were also characterized by PXRD, SEM microscopy, UV-Vis and Raman spectroscopy, TG and DSC. ETS-4Cu presents higher NO adsorption capacity (up to 4.5 mmol g-1 solid) comparing with the parent material, excellent stability in biological media and exhibits high compatibility in different cell lines, including primary keratinocytes (HEKn). Its NO release profile in biological conditions demonstrated a controlled release over at least 4 h, never achieved by any other porous materials so far. This may be reflected by its peculiar NO adsorption mechanism through the formation of stable nitro species on the framework.
DOI http://dx.doi.org/10.1016/j.micromeso.2021.111154
ISBN
Publisher
Book Title
ISSN 1387-1811
EISSN 1873-3093
Conference Name
Bibtex ID ISI:000660462500001
Observations
Back to Publications List