Publication Type Journal Article
Title An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and Underlying Resistance Mechanisms in Clinical Strains
Authors Sara B. Salazar Rita S. Simoes Nuno A. Pedro Maria Joana Pinheiro M Fernanda NN Carvalho Nuno P. Mira
Groups BioMol
Journal JOURNAL OF FUNGI
Year 2020
Month March
Volume 6
Number 1
Pages
Abstract Fungal infections and, in particular, those caused by species of the Candida genus, are growing at an alarming rate and have high associated rates of mortality and morbidity. These infections, generally referred as candidiasis, range from common superficial rushes caused by an overgrowth of the yeasts in mucosal surfaces to life-threatening disseminated mycoses. The success of currently used antifungal drugs to treat candidiasis is being endangered by the continuous emergence of resistant strains, specially among non-albicans Candida species. In this review article, the mechanisms of action of currently used antifungals, with emphasis on the mechanisms of resistance reported in clinical isolates, are reviewed. Novel approaches being taken to successfully inhibit growth of pathogenic Candida species, in particular those based on the exploration of natural or synthetic chemicals or on the activity of live probiotics, are also reviewed. It is expected that these novel approaches, either used alone or in combination with traditional antifungals, may contribute to foster the identification of novel anti-Candida therapies.
DOI http://dx.doi.org/10.3390/jof6010023
ISBN
Publisher
Book Title
ISSN
EISSN 2309-608X
Conference Name
Bibtex ID ISI:000530143200022
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