Publication Type Journal Article
Title Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy
Authors Sara Fernandes Rosa Fernandes Bruno Sarmento Patricia M. R. Pereira João P. C. Tomé
Groups CCC
Journal ORGANIC \& BIOMOLECULAR CHEMISTRY
Year 2019
Month March
Volume 17
Number 10
Pages 2579-2593
Abstract Photodynamic therapy (PDT) combines a photosensitizer (PS) with the physical energy of non-ionizing light to trigger cell death pathways. PDT has potential as a therapeutic modality to be used in alternative or in combination with other conventional cancer treatment protocols (e. g. surgery, chemotherapy and radiotherapy). Still, due to the lack of specificity of the current PSs to target the tumor cells, several studies have exploited their conjugation with targeting moieties. PSs conjugated with antibodies (Abs) or their fragments, able to bind antigens overexpressed in the tumors, have demonstrated potential in PDT of tumors. This review provides an overview of the most recent advances on photoimmunoconjugates (PICs) for cancer PDT, which involve the first and second-generation PSs conjugated to Abs. This is an update of our previous review Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications , published in 2015 in Org. Biomol. Chem.
DOI http://dx.doi.org/10.1039/c8ob02902d
ISBN
Publisher
Book Title
ISSN 1477-0520
EISSN 1477-0539
Conference Name
Bibtex ID ISI:000460594400031
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