Publication Type Journal Article
Title SPIONs Prepared in Air through Improved Synthesis Methodology: the Influence of gamma-Fe2O3/Fe3O4 Ratio and Coating Composition on Magnetic Properties
Authors Joana C. Matos M. Clara Gonçalves Laura C. J. Pereira Bruno J. C. Vieira Joao Carlos Waerenborgh
Groups MPPM
Journal NANOMATERIALS
Year 2019
Month July
Volume 9
Number 7
Pages
Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) have shown great potential in biomedicine due to their high intrinsic magnetization behaviour. These are small particles of magnetite or maghemite, and when coated, their surface oxidation is prevented, their aggregation tendency is reduced, their dispersity is improved, and the stability and blood circulation time are increased, which are mandatory requirements in biomedical applications. In this work, SPIONs were synthesized in air through a reduction-precipitation method and coated with four different polymers (Polyethylene glycol(PEG) 1000/6000 and dextran T10/T70). All the synthesized samples were structurally and magnetically characterized by transmission electron microscopy, Fourier transform infra-red spectroscopy, X-ray powder diffraction, Mossbauer spectroscopy, and Superconducting Quantum Interference Device (SQUID) magnetometry. SPIONs centrifuged and dried in vacuum with an average diameter of at least 7.5 nm and a composition <= 60\% of maghemite and >= 40\% of magnetite showed the best magnetization results, namely a saturation magnetization of 64 emu/g at 300 K, similar to the best reported values for SPIONs prepared in controlled atmosphere. As far as SPIONs coatings are concerned, during their preparation procedure, surface polymers must be introduced after the SPIONs precipitation. Furthermore, polymers with shorter chains do not affect the SPIONs magnetization performance, although longer chain polymers significantly decrease the coated particle magnetization values, which is undesirable.
DOI http://dx.doi.org/10.3390/nano9070943
ISBN
Publisher
Book Title
ISSN 2079-4991
EISSN
Conference Name
Bibtex ID ISI:000478992600031
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