Publication Type Journal Article
Title Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction
Authors Catarina Garcia Catarina Oliveira Silva Carlos M. Monteiro M. Nicolai A. Viana Joana M. Andrade Isabel Barasoain Tijana Stankovic Jose Quintana Inmaculada Hernandez Ignacio Gonzalez Francisco Estevez Ana M. Diaz-Lanza Catarina Pinto Reis Carlos A. M. Afonso Milica Pesic Patricia Rijo
Groups Chem4Env
Journal FUTURE MEDICINAL CHEMISTRY
Year 2018
Month May
Volume 10
Number 10
Pages 1177-1189
Abstract Aim: 6,7-dehydroroyleanone (DHR) is a cytotoxic abietane present in the essential oil of Plectranthus madagascariensis. Methods/results: Different extraction parameters were tested, and its extraction optimization was accomplished with a Clevenger apparatus-based hydrodistillation. After isolation, its effect on microtubules, P-glycoprotein and caspases was assessed on several cell lines and the compound was coupled with hybrid nanoparticles. The results show that DHR does not interfere with microtubule formation, but evades the resistance mechanisms of P-glycoprotein. Strong activation of caspases-3 and -9 indicates that DHR is able to induce apoptosis by triggering the intrinsic cell death pathway. Moreover, the assembly of DHR with hybrid nanoparticles was able to potentiate the effect of DHR in cancer cells. Conclusion: DHR seems to be a promising starting material with anticancer properties to further be explored.
DOI http://dx.doi.org/10.4155/fmc-2017-0239
ISBN
Publisher
Book Title
ISSN 1756-8919
EISSN 1756-8927
Conference Name
Bibtex ID ISI:000433568500005
Observations
Back to Publications List