Publication Type Journal Article
Title Biocompatible hybrids based on nanographene oxide covalently linked to glycolporphyrins: Synthesis, characterization and biological evaluation
Authors Carla I. M. Santos Gil Goncalves Monica Cicuendez Ines de Fatima A. Mariz Virgilia S. Silva Helena Oliveira Fabio Campos Sandra I. Vieira Paula A. A. P. Marques Ermelinda Macoas M. Graca P. M. S. Neves J. M. G. Martinho
Groups MPPM
Journal CARBON
Year 2018
Month August
Volume 135
Number
Pages 202-214
Abstract The major limitation in the development of hybrids based on graphene oxide (GO) and porphyrins is their dispersibility and stability in aqueous systems due to the hydrophobic character induced by porphyrins. Most of the previous approaches reported the direct functionalization of GO with polyethylene glycol (PEG) chains followed by the self-assembly of porphyrins by pi-pi interactions. Here, new hybrids were prepared using porphyrins previously functionalized with different number/types of glycol branches to be covalently attached through esterification to the carboxyl groups of GO sheets of nano-metric dimensions. The number of the glycol chains and its relative position in the porphyrin core showed to be fundamental to improve the hybrids dispersion and stability in aqueous solutions. The best performing hybrids were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared, UV-Vis absorption and fluorescence spectroscopy. The in vitro biocompatibility assessment of these hybrids was conducted using human Saos-2 cells. Their effects on cell proliferation and viability, the generation of reactive oxygen species as well as the cell morphology after cell uptake were analysed. The results demonstrate the biocompatibility of these hybrid nano-materials with human Saos-2 cells, which is very promising for future application in biomedicine namely in cancer therapy. (C) 2018 Elsevier Ltd. All rights reserved.
DOI http://dx.doi.org/10.1016/j.carbon.2018.04.040
ISBN
Publisher
Book Title
ISSN 0008-6223
EISSN 1873-3891
Conference Name
Bibtex ID ISI:000436800100023
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