Publication Type Journal Article
Title A Galactose Dendritic Silicon (IV) Phthalocyanine as a Photosensitizing Agent in Cancer Photodynamic Therapy
Authors Mafalda Bispo Patricia M. R. Pereira Francesca Setaro M. Salome Rodriguez-Morgade Rosa Fernandes Tomas Torres João P. C. Tomé
Groups CCC
Journal CHEMPLUSCHEM
Year 2018
Month September
Volume 83
Number 9
Pages 855-860
Abstract Two protected galacto-dendritic units have been axially coordinated to the central ion of a silicon(IV) phthalocyanine to afford SiPcPGal(4) containing four units of galactose per macrocycle. These biological moieties provided better solubility in aqueous medium and a sensitizer with higher absorption peaks at 680-690 nm. The photodynamic activity of SiPcPGal(4) was evaluated against UM-UC-3 human bladder cancer cell line and the results were compared with the activity of the reported SiPcPGal(2) and SiPc(OH)(2). SiPcPGal(4) had a better uptake and it was a better toxicity inducer than SiPcPGal(2) and SiPc(OH)(2) owing to its four galactose units, protected by isopropylidene groups, which can act as targeted micelles.
DOI http://dx.doi.org/10.1002/cplu.201800370
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Publisher
Book Title
ISSN 2192-6506
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Conference Name
Bibtex ID ISI:000445850300007
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