Publication Type Journal Article
Title A Cationic Smart Copolymer for DNA Binding
Authors Tânia Ribeiro Ana Margarida Santiago J. M. G. Martinho José Paulo Farinha
Groups
Journal POLYMERS
Year 2017
Month November
Volume 9
Number 11
Pages
Abstract A new block copolymer with a temperature-responsive block and a cationic block was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization, with good control of its size and composition. The first block is composed by di(ethylene glycol) methyl ether methacrylate (DEGMA) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA), with the ratio DEGMA/OEGMA being used to choose the volume phase transition temperature of the polymer in water, tunable from ca. 25 to above 90 degrees C. The second block, of trimethyl-2-methacroyloxyethylammonium chloride (TMEC), is positively charged at physiological pH values and is used for DNA binding. The coacervate complexes between the block copolymer and a model single strand DNA are characterized by fluorescence correlation spectroscopy and fluorescence spectroscopy. The new materials offer good prospects for biomedical application, for example in controlled gene delivery.
DOI http://dx.doi.org/10.3390/polym9110576
ISBN
Publisher
Book Title
ISSN 2073-4360
EISSN
Conference Name
Bibtex ID ISI:000416807600029
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