Publication Type Journal Article
Title Biofunctional composite coating architectures based on polycaprolactone and nanohydroxyapatite for controlled corrosion activity and enhanced biocompatibility of magnesium AZ31 alloy
Authors A. Zomorodian M. P. Garcia T. M. Silva JCS Fernandes Maria F. Montemor
Groups CSSE
Journal MATERIALS SCIENCE \& ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Year 2015
Month March
Volume 48
Number
Pages 434-443
Abstract In this work a biofunctional composite coating architecture for controlled corrosion activity and enhanced cellular adhesion of AZ31 Mg alloys is proposed. The composite coating consists of a polycaprolactone (PCL) matrix modified with nanohydroxyapatite (HA) applied over a nanometric layer of polyetherimide (PEI). The protective properties of the coating were studied by electrochemical impedance spectroscopy (EIS), a non-disturbing technique, and the coating morphology was investigated by field emission scanning electron microscopy (FE-SEM). The results show that the composite coating protects the AZ31 substrate. The barrier properties of the coating can be optimized by changing the PCL concentration. The presence of nanohydroxyapatite particles influences the coating morphology and decreases the corrosion resistance. The biocompatibility was assessed by studying the response of osteoblastic cells on coated samples through resazurin assay, confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM). The results show that the polycaprolactone to hydroxyapatite ratio affects the cell behavior and that the presence of hydroxyapatite induces high osteoblastic differentiation. (C) 2014 Elsevier B.V. All rights reserved.
DOI http://dx.doi.org/10.1016/j.msec.2014.12.027
ISBN
Publisher
Book Title
ISSN 0928-4931
EISSN 1873-0191
Conference Name
Bibtex ID ISI:000348749200056
Observations
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