Publication Type Journal Article
Title Synthetic cobalt clays for the storage and slow release of therapeutic nitric oxide
Authors A C Fernandes Moises L. Pinto F. J. N. Antunes J. M. P. Silva
Groups
Journal RSC ADVANCES
Year 2016
Month
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Volume 6
Number 47
Pages 41195-41203
Abstract Nitric oxide (NO) is one of the smallest endogenous molecules with particularly interesting aspect roles in biological systems, despite its toxicological potential. Solid carriers have potential biomedical interest in the delivery of exogenous NO for anti-bacterial, anti-thrombic and wound healing applications. In this work, a smectite clay was successfully synthetized with incorporated cobalt ions in its structure, with the main goal of studying its potential in the field of storage and release of nitric oxide for therapeutic applications. Materials were characterized by X-ray diffraction, nitrogen adsorption at -196 degrees C, TG-DSC and chemical analysis. The kinetic data for the nitric oxide storage and release was obtained in gas and in liquid phases. The released amounts of NO in the liquid phase were within the biological range and slow release kinetics were obtained with, inclusively, an almost direct relation between the released fraction and time. Toxicological assays with HeLa cells indicated that the materials have low cytotoxicity.
DOI http://dx.doi.org/10.1039/c6ra05794b
ISBN
Publisher
Book Title
ISSN 2046-2069
EISSN
Conference Name
Bibtex ID ISI:000375270600074
Observations
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