| Publication Type |
Journal Article |
| Title |
Facile Regioselective Synthesis of a Novel Chitosan-Pexiganan Conjugate with Potential Interest for the Treatment of Infected Skin Lesions |
| Authors |
Mary K. S. Batista Marcal Gallemi Alberto Adeva C. A. R. Gomes P Gomes |
| Groups |
|
| Journal |
SYNTHETIC COMMUNICATIONS |
| Year |
2009 |
| Month |
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|
| Volume |
39 |
| Number |
7 |
| Pages |
1228-1240 |
| Abstract |
A pexiganan-chitosan conjugate was designed to combine the exceptional bioadhesion and tissue-regenerating abilities of chitosan with the excellent antibiotic properties of pexiganan. We herein report our first results on the successful synthesis, including Fourier transform infrared (FT-IR) and amino acid analysis of such conjugate, which was prepared by regioselective covalent attachment of a Cys-containing pexiganan analog to the chitosan s amino groups. Further results from ongoing research will be reported. |
| DOI |
http://dx.doi.org/10.1080/00397910802517855 |
| ISBN |
|
| Publisher |
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| Book Title |
|
| ISSN |
0039-7911 |
| EISSN |
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| Conference Name |
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| Bibtex ID |
ISI:000263875000010 |
| Observations |
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