Publication Type Journal Article
Title First solid-state NMR spectroscopy evaluation of complexes of benznidazole with cyclodextrin derivatives
Authors Josefina Priotti M J Ferreira Maria C. Lamas Dario Leonardi Claudio J. Salomon Teresa G. Nunes
Groups BioMol
Journal CARBOHYDRATE POLYMERS
Year 2015
Month October
Volume 131
Number
Pages 90-97
Abstract Complexation of benznidazole (BZL), a drug of choice for the treatment of Chagas neglected disease, with cyclodextrin (CD) derivatives was analyzed by solid-state NMR. C-13 cross polarization/magic angle spinning spectra were recorded from BZL and from BZL:beta-CD, BZL:methyl beta-CD and BZL:hydroxypropyl beta-CD complexes, which were obtained by the solvent evaporation technique. No significant evidence was obtained on BZL inclusion complexes involving either beta-CD or hydroxypropyl beta-CD. Conversely, BZL:methyl beta-CD displayed BZL resonances characteristic of an amorphous drug and data analysis confirmed the presence of stable BZL:methyl beta-CD inclusion complexes, with benzene encapsulated into the host cavity. Further evidences on complex structure and dynamics were obtained from proton and carbon spin-lattice relaxation times in the rotating frame. These data are consistent with a common guest-host spin reservoir. The BZL interaction with methyl beta-CD provided a route to stabilize amorphous BZL. Physical mixtures with identical BZL and CD compositions were also studied for comparison. (C) 2015 Elsevier Ltd. All rights reserved.
DOI http://dx.doi.org/10.1016/j.carbpol.2015.05.045
ISBN
Publisher ELSEVIER SCI LTD
Book Title
ISSN 0144-8617
EISSN 1879-1344
Conference Name
Bibtex ID ISI:000361183600012
Observations
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