Publication Type Journal Article
Title Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands
Authors Virtudes Moreno Julia Lorenzo Francesc X. Aviles M. Helena Garcia Joao P. Ribeiro Tânia S. Morais Pedro Florindo M Paula Robalo
Groups BIOIN BioMol
Journal BIOINORGANIC CHEMISTRY AND APPLICATIONS
Year 2010
Month
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Abstract Four cationic ruthenium(II) complexes with the formula [Ru(eta(5)-C(5)H(5))(PPh(3))(2)](+), with L = 5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b; 4,3-b ] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs. Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).
DOI http://dx.doi.org/10.1155/2010/936834
ISBN
Publisher HINDAWI PUBLISHING CORPORATION
Book Title
ISSN 1565-3633
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Bibtex ID ISI:000280798600001
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