| Abstract |
C-13 and N-15 solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:beta-cyclodextrin, ABZ:methyl-P-cyclodextrin, ABZ:hydroxypropyl-beta-cyclodextrin and ABZ:citrate-beta-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes. (C) 2015 Elsevier Ltd. All rights reserved. |
