| Publication Type |
Journal Article |
| Title |
In vitro corrosion behaviour and anti-Candida spp. activity of Zn coated with ZnO-nanostructured Anastacia flowers |
| Authors |
Marta M. Alves Diana V. Cunha C. Santos Nuno P. Mira Maria F. Montemor |
| Groups |
CSSE |
| Journal |
JOURNAL OF MATERIALS CHEMISTRY B |
| Year |
2016 |
| Month |
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|
| Volume |
4 |
| Number |
27 |
| Pages |
4754-4761 |
| Abstract |
Rejection and colonization by microbes are two problematic issues that often require the surgical removal of medical implants with increased risks for patients. In this work it is shown that functionalization of Zn surfaces with ZnO-nanostructured Anastacia flowers (NAF) resulted in improved biomaterials that can potentially overcome these important drawbacks, which can further boost the use of Zn in biomedical implants. The in vitro degradation of NAF-coated Zn under simulated physiological conditions resulted in the formation of a biomimetic corrosion layer rich in a hydroxyapatite analogue that, being an important bone component, may potentially decrease implant rejection. Colonization of the NAF-coated Zn surface by Candida parapsilosis and Candida albicans, two of the more relevant microbial species colonizing medical devices, was significantly reduced on the NAF-coated Zn surface. The mechanism by which this colonization inhibition occurred was distinct since for C. parapsilosis cells this was attributed to reduced cell viability, while for C. albicans the reduced colonization was related to impaired biofilm formation. This ZnO-derived coating is an expeditious strategy to improve the resilience of Zn-based resorbable biomaterials towards Candida spp. colonization, paving the way for the design of bioactive ZnO-derived coatings with potential for clinical applications on bone. |
| DOI |
http://dx.doi.org/10.1039/c6tb00797j |
| ISBN |
|
| Publisher |
ROYAL SOC CHEMISTRY |
| Book Title |
|
| ISSN |
2050-750X |
| EISSN |
2050-7518 |
| Conference Name |
|
| Bibtex ID |
ISI:000379491000017 |
| Observations |
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