Publication Type Journal Article
Title Sulfonated Schiff base Sn(IV) complexes as potential anticancer agents
Authors Susanta Hazra A. Paul Gunjan Sharma Biplob Koch M. Fátima C. Guedes da Silva Armando J.L. Pombeiro
Groups CCC
Journal JOURNAL OF INORGANIC BIOCHEMISTRY
Year 2016
Month September
Volume 162
Number
Pages 83-95
Abstract Syntheses, crystal structures and biological activities of the diphenoxo-bridged diorgano dinuclear Sn(IV) compounds [Sn(Et)(2)(HL)(H2O)](2) (1) and Sn(n-Bu)(2)( HL)(H2O)](2) (2) derived from the Schiff base 2-1(2,3-dihydroxyphenyl)methylideneamino]benzenesulfonic acid trihydrate (H3L center dot 3H(2)O) are described. The monoprotonated form (HL2-) of the Schiff base behaves as O,O -bidentate ligand, chelating the metal by the two phenoxo oxygen atoms. The hexacoordinated metal centres in 1 and 2 are bridged by a phenoxo oxygen and the remaining coordination positions are fulfilled by the other phenoxo oxygen, two organic groups (ethyl for 1 and n-butyl for 2) and a water molecule. A two dimensional zigzag sheet in 1 and three dimensional polymeric networks in H3L center dot 3H(2)O and 2 are stabilized by a number of non-covalent, H-bonding and pi...pi stacking interactions. The DNA binding activities of these complexes have been studied by UV-vis and fluorescence spectroscopies. Their antiproliferative efficacies have been evaluated on A-549, HeLa and MDA-MB-231 cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MIT) assay. IC50 values (1.35 +/- 023, 2.43 +/- 0.54 and 1.74 +/- 0.04 mu M for 2) are indicative of a substantial cytotoxicity of 2, mainly towards the A-549 lung cancer cell line. The greater antiproliferative efficacy of 2 has further been studied by fluorescence activated cell sorting (FACS) and nuclear morphology by Hoechst/propidium iodide (PI) double staining method. The possible mode of the apoptotic pathway for 2 has been substantiated by the reactive oxygen species (ROS) generation studies. (C) 2016 Elsevier Inc. All rights reserved.
DOI http://dx.doi.org/10.1016/j.jinorgbio.2016.06.008
ISBN
Publisher ELSEVIER SCIENCE INC
Book Title
ISSN 0162-0134
EISSN 1873-3344
Conference Name
Bibtex ID ISI:000388059600009
Observations
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