Publication Type Journal Article
Title Unfolding biological properties of a versatile dicopper(II) precursor and its two mononuclear copper(II) derivatives
Authors A. Paul Susanta Hazra Gunjan Sharma M. Fátima C. Guedes da Silva Biplob Koch Armando J.L. Pombeiro
Groups CCC
Journal JOURNAL OF INORGANIC BIOCHEMISTRY
Year 2017
Month September
Volume 174
Number
Pages 25-36
Abstract Synthesis, inter-conversions and biological study of the dichloro bridged dicopper(II) compound [CuLCl](2) (1) and its two mononuclear derivatives [CuLCl(H2O)]center dot H2O (2) and [CuLCl(py)] (3) (HL = 2-(2-pyridylmethyleneamino)benzenesulfonic acid) are described. The dimeric compound 1 collapses into monomers 2 and 3 in the presence of coordinating solvents, water and pyridine, respectively, and 1 is regenerated upon simple stirring of 2 or 3 in methanol. The reactions of 1 with neutral (present study) and charged (earlier studies) ligands result in monomeric and multimeric compounds, respectively, attesting that it is a versatile dicopper(II) precursor. The anticancer activity of these copper complexes (1-3) was screened against lung (A-549) and breast (MDA-MB-231) human cancer cell lines. The IC50 (half maximal inhibitory concentration) value for one (3) of the compounds suggests preferential cytotoxicity against breast cancer MDA-MB-231 cell line. Furthermore, the IC50 value obtained for complex 3 is found to be almost two-fold times cytotoxic than the standard drug cisplatin. In addition, the underlying possible mechanism of its apoptosis-inducing efficacy in MDA-MB-231 cells has been rationalized by using flow cytometry (FACS) and Hoechst 33342/propidium iodide (PI) fluorescence staining. The stimulation of apoptotic induction for complex 3 has further been affirmed by reactive oxygen species (ROS) generation and mitochondrial aggregations studies.
DOI http://dx.doi.org/10.1016/j.jinorgbio.2017.05.013
ISBN
Publisher ELSEVIER SCIENCE INC
Book Title
ISSN 0162-0134
EISSN 1873-3344
Conference Name
Bibtex ID ISI:000406647700003
Observations
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