| Publication Type |
Journal Article |
| Title |
Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands |
| Authors |
M. Helena Garcia Tânia S. Morais Pedro Florindo M.Fatima M.Piedade Virtudes Moreno Carlos Ciudad Veronica Noe |
| Groups |
BIOIN BioMol |
| Journal |
JOURNAL OF INORGANIC BIOCHEMISTRY |
| Year |
2009 |
| Month |
March |
| Volume |
103 |
| Number |
3 |
| Pages |
354-361 |
| Abstract |
Inhibition of the growth of LoVo human colon adenocarcinoma and MiaPaCa pancreatic cancer cell lines by two new organometallic ruthenium(II) complexes of general formula [Ru(eta(5)-C5H5)(PP) L][CF3SO3], where PP is 1,2-bis(diphenylphosphino)ethane and L is 1,3,5-triazine (Tzn) 1 or PP is 2x triphenylphosphine and L is pyridazine (Pyd) 2 has been investigated. Crystal structures of compounds I and 2 were determined by X-ray diffraction studies. Atomic force microscopy (AFM) images suggest different mechanisms of interaction with the plasmid pBR322 DNA; while the mode of binding of compound 1 could be intercalation between base pairs of DNA, compound 2 might be involved in a covalent bond formation with N from the purine base. (C) 2008 Elsevier Inc. All rights reserved. |
| DOI |
http://dx.doi.org/10.1016/j.jinorgbio.2008.11.016 |
| ISBN |
|
| Publisher |
ELSEVIER SCIENCE INC |
| Book Title |
|
| ISSN |
0162-0134 |
| EISSN |
|
| Conference Name |
|
| Bibtex ID |
ISI:000263693900006 |
| Observations |
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