Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer s agents: AChE inhibition, antioxidant activity and metal chelating capacity
JOURNAL OF INORGANIC BIOCHEMISTRY, 163, 266-277 10 2016
Karam Chand , Hesham M. Alsoghier , Sílvia Chaves , M. Amélia Santos

Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles
JOURNAL OF INORGANIC BIOCHEMISTRY, 151, 58-66 10 2015
Catarina Quintanova , Rangappa S. Keri , Sílvia Chaves , M. Amélia Santos

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 89, 340-348 1 2015
Olayiwola A. Adekoya , Stian Sjoli , Yimingjiang Wuxiuer , Irma Bilto , Sergio M. Marques , M. Amélia Santos , Elisa Nuti , Giovanni Cercignani , Armando Rossello , Jan-Olof Winberg , Ingebrigt Sylte

Design, synthesis and bioevaluation of tacrine hybrids with cinnamate and cinnamylidene acetate derivatives as potential anti-Alzheimer drugs
MedChemComm, 6, 1969-1977 2015
Catarina Quintanova , Rangappa S. Keri , Sergio M. Marques , Maria G-Fernandes , Sandra M. Cardoso , Maria L. Serralheiro , M. Amélia Santos

Benzofuran: an emerging scaffold for antimicrobial agents
RSC ADVANCES, 5, 96809-96828 2015
Asha Hiremathad , Mahadeo R. Patil , K. R. Chethana , Karam Chand , M. Amélia Santos , Rangappa S. Keri

3-hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use
FUTURE MEDICINAL CHEMISTRY, 7, 383-410 2015
M. Amélia Santos , Sílvia Chaves

Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 100, 257-269 7 2015
Rangappa S. Keni , B. S. Sasidhar , Bhari Mallanna Nagaraja , M. Amélia Santos

A new bis-3-hydroxy-4-pyrone as a potential therapeutic iron chelating agent. Effect of connecting and side chains on the complex structures and metal ion selectivity
JOURNAL OF INORGANIC BIOCHEMISTRY, 141, 132-143 12 2014
V. M. Nurchi , G. Crisponi , Massimiliano Arca , Miriam Crespo-Alonso , J. I. Lachowicz , Delara Mansoori , Leonardo Toso , Giuseppina Pichiri , M. Amélia Santos , Sergio M. Marques , Juan Niclos-Gutierrez , Josefa M. Gonzalez-Perez , Alicia Dominguez-Martin , D. Choquesillo-Lazarte , Z. Szewczuk , M. Antonietta Zoroddu , M. Peana

Searching for new aluminium chelating agents: A family of hydroxypyrone ligands
JOURNAL OF INORGANIC BIOCHEMISTRY, 130, 112-121 1 2014
Leonardo Toso , G. Crisponi , V. M. Nurchi , Miriam Crespo-Alonso , J. I. Lachowicz , Delara Mansoori , Massimiliano Arca , M. Amélia Santos , Sergio M. Marques , Lurdes Gano , Juan Niclos-Gutierrez , Josefa M. Gonzalez-Perez , Alicia Dominguez-Martin , D. Choquesillo-Lazarte , Z. Szewczuk

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy
JOURNAL OF INORGANIC BIOCHEMISTRY, 127, 188-202 10 2013
Sergio M. Marques , Claudia C. Abate , Sílvia Chaves , Fernanda M. Marques , Isabel Santos , Elisa Nuti , Armando Rossello , M. Amélia Santos

A family of hydroxypyrone ligands designed and synthesized as iron chelators
JOURNAL OF INORGANIC BIOCHEMISTRY, 127, 220-231 10 2013
Leonardo Toso , G. Crisponi , V. M. Nurchi , Miriam Crespo-Alonso , J. I. Lachowicz , M. Amélia Santos , Sergio M. Marques , Juan Niclos-Gutierrez , Josefa M. Gonzalez-Perez , Alicia Dominguez-Martin , D. Choquesillo-Lazarte , Z. Szewczuk

Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer s disease
BIOORGANIC \& MEDICINAL CHEMISTRY, 21, 4559-4569 8 2013
Rangappa S. Keri , Catarina Quintanova , Sergio M. Marques , A. Raquel Esteves , Sandra M. Cardoso , M. Amélia Santos

Chemistry and applications of metal complexes
DALTON TRANSACTIONS, 42, 5857-5859 2013
M. Amélia Santos

A novel tripodal tris-hydroxypyrimidinone sequestering agent for trivalent hard metal ions: synthesis, complexation and in vivo studies
DALTON TRANSACTIONS, 42, 6033-6045 2013
Sílvia Chaves , Anabela Capelo , Laurinda Areias , Sergio M. Marques , Lurdes Gano , M. Alexandra Esteves , M. Amélia Santos

New tris-3,4-HOPO lanthanide complexes as potential imaging probes: complex stability and magnetic properties
DALTON TRANSACTIONS, 42, 6046-6057 2013
Ana C. Mendonca , Andre F. Martins , Andrea Melchior , Sergio M. Marques , Sílvia Chaves , Sandrine Villette , Stephane Petoud , Pier Luigi Zanonato , Marilena Tolazzi , Celia S. Bonnet , Eva Toth , Plinio Di Bernardo , Carlos F. G. C. Geraldes , M. Amélia Santos

Multifunctional iron- chelators with protective roles against neurodegenerative diseases
DALTON TRANSACTIONS, 42, 6058-6073 2013
Andreia Nunes , Sergio M. Marques , Catarina Quintanova , Diana F. Silva , Sandra M. Cardoso , Sílvia Chaves , M. Amélia Santos

Hydroxy(thio)pyrone and hydroxy(thio)pyridinone iron chelators: Physico-chemical properties and anti-oxidant activity
JOURNAL OF INORGANIC BIOCHEMISTRY, 114, 38-46 9 2012
Sílvia Chaves , Sonia Canario , Marta P. Carrasco , Lurdes Mira , M. Amélia Santos

Hydroxypyri(mi)dine-Based Chelators as Antidotes of Toxicity Due to Aluminum and Actinides
CURRENT MEDICINAL CHEMISTRY, 19, 2773-2793 6 2012
M. Amélia Santos , M. Alexandra Esteves , Sílvia Chaves

Hydroxypyridinones as privileged chelating structures for the design of medicinal drugs
COORDINATION CHEMISTRY REVIEWS, 256, 240-259 1 2012
M. Amélia Santos , Sergio M. Marques , Sílvia Chaves

Novel 1-Hydroxypiperazine-2,6-diones as New Leads in the Inhibition of Metalloproteinases
JOURNAL OF MEDICINAL CHEMISTRY, 54, 8289-8298 12 2011
Sergio M. Marques , Tiziano Tuccinardi , Elisa Nuti , Salvatore Santamaria , Vânia André , Armando Rossello , Adriano Martinelli , M. Amélia Santos