Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21, 6 2020
Madalena Cipriano , Pedro F. Pinheiro , Catarina O. Sequeira , Joana S. Rodrigues , Nuno G. Oliveira , Alexandra Maria Moita Antunes , Matilde Castro , M. Matilde Marques , Sofia A. Pereira , Joana P. Miranda

Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 172, 16-25 6 2019
Claudia Braga , Ana R. Vaz , M. Conceição Oliveira , M. Matilde Marques , Rui Moreira , Dora Brites , Maria J. Perry

Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors
MOLECULES, 24, 6 2019
Mohamed Y. Mahgoub , Awatef M. Elmaghraby , Abd-Elfttah A. Harb , João Ferreira da Silva , Gonçalo C. Justino , M. Matilde Marques

Advisory Group recommendations on priorities for the IARC Monographs
LANCET ONCOLOGY, 20, 763-764 6 2019
M. Matilde Marques , A. Berrington de Gonzalez , F. A. Beland , P. Browne , P. A. Demers , D. W. Lachenmeier , T. Bahadori , D. K. Barupal , F. Belpoggi , P. Comba , R. D. Daniels , C. Ferreccio , O. A. Grigoriev , Y. C. Hong , R. N. Hoover , J. Kanno , M. Kogevinas , G. Lasfargues , R. Malekzadeh , S. Masten , R. Newton , T. Norat , J. J. Pappas , C. Queiroz Moreira , T. Rodriguez , J. Rodriguez-Guzman , V. Sewram , L. Zeise , IARC Monographs Priorities Grp

Advisory Group recommendations on priorities for the IARC Monographs
LANCET ONCOLOGY, 20, 763-764 6 2019
M. Matilde Marques , A. Berrington de Gonzalez , F. A. Beland , P. Browne , P. A. Demers , D. W. Lachenmeier , T. Bahadori , D. K. Barupal , F. Belpoggi , P. Comba , R. D. Daniels , C. Ferreccio , O. A. Grigoriev , Y. C. Hong , R. N. Hoover , J. Kanno , M. Kogevinas , G. Lasfargues , R. Malekzadeh , S. Masten , R. Newton , T. Norat , J. J. Pappas , C. Queiroz Moreira , T. Rodriguez , J. Rodriguez-Guzman , V. Sewram , L. Zeise , IARC Monographs Priorities Grp

Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity
DRUG METABOLISM REVIEWS, 51, 76-90 1 2019
Aline T. Marinho , Joana P. Miranda , Umbelina Caixas , Catarina Charneira , Clara Goncalves-Dias , M. Matilde Marques , Emilia C. Monteiro , Alexandra Maria Moita Antunes , Sofia A. Pereira

Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics
CURRENT MEDICINAL CHEMISTRY, 26, 7285-7322 2019
Sara N. Garcia , Rita C. Guedes , M. Matilde Marques

High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 119, 70-82 7 2018
Ana L. A. Godinho , Ines L. Martins , Joao Nunes , Catarina Charneira , Jorge Grilo , Diogo M. Silva , Sofia A. Pereira , Karina Soto , M. Conceição Oliveira , M. Matilde Marques , Cristina C. Jacob , Alexandra M. M. Antunes

The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals
FREE RADICAL BIOLOGY AND MEDICINE, 129, 559-568 12 2018
Ines L. Martins , Joao Nunes , Catarina Charneira , Judit Morello , Sofia A. Pereira , J. P. Telo , M. Matilde Marques , Alexandra Maria Moita Antunes

How far can we use human serum transferrin to transport drugs?
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256, 8 2018
Jose Justino , M. Matilde Marques

Adverse reactions induced by the antiepileptic drug oxcarbazepine may stem from its metabolic biotransformation to carbamazepine
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256, 8 2018
Ines L. Martins , Catarina Charneira , M. Matilde Marques , Alexandra Antunes

Inducing the activity of NK cells with NKp30 small organic ligands
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256, 8 2018
Pedro F. Pinheiro , Goncalo Justino , Joana Miranda , M. Matilde Marques

Predicting drug metabolites using bacterial-based models
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256, 8 2018
Pedro Rosado , Josimar Cruz , Marta Justino , M. Matilde Marques , Jose Justino

Carcinogenicity of isobutyl nitrite, beta-picoline, and some acrylates
LANCET ONCOLOGY, 19, 1020-1022 8 2018
Hans Kromhout , Melissa Friesen , M. Matilde Marques , Consolato Maria Sergi , Mohamed Abdallah , Geza Benke , Mark Cesta , Dori Germolec , Keith Houck , Gaku Ichihara , Charles William Jameson , Jun Kanno , Igor Pogribny , Camilla Svendsen , Lamia Benbrahim-Tallaa , Kathryn Z. Guyton , Yann Grosse , Fatiha El Ghissassi , Veronique Bouvard , Amy Hall , Corentin Jaillet , Heidi Mattock , Kurt Straif , Int Agcy Res Canc Monograph Wor

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study
ARCHIVES OF TOXICOLOGY, 91, 1199-1211 3 2017
Pedro F. Pinheiro , Sofia A. Pereira , Shrika G. Harjivan , Inês Sofia Lança Martins , Aline T. Marinho , Madalena Cipriano , Cristina C. Jacob , Nuno G. Oliveira , Matilde F. Castro , M. Matilde Marques , Alexandra Maria Moita Antunes , Joana P. Miranda

Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study
FOOD AND CHEMICAL TOXICOLOGY, 99, 170-181 1 2017
Linda S. Von Tungeln , Nigel J. Walker , Greg R. Olson , Maria C. B. Mendoza , Robert P. Felton , Brett T. Thorn , M. Matilde Marques , Igor P. Pogribny , Daniel R. Doerge , Frederick A. Beland

Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 105, 47-54 7 2017
Nadia M. Grilo , M. Joao Correia , Joana P. Miranda , Madalena Cipriano , Jacinta Serpa , M. Matilde Marques , Emilia C. Monteiro , Alexandra Maria Moita Antunes , Lucilia N. Diogo , Sofia A. Pereira

Toxic events induced by the antiepileptic drug carbamazepine: Is bioactivation really involved?
TOXICOLOGY LETTERS, 280, S241 10 2017
Alexandra M. M. Antunes , Ines L. Martins , J. Paulo Telo , M. Matilde Marques

3D in vitro cultures of human hepatocyte-like cells as an alternative competent model for nevirapine biotransformation studies
TOXICOLOGY LETTERS, 280, S263 10 2017
Madalena Cipriano , Pedro F. Pinheiro , Catarina Sequeira , Jorge M. Santos , Nuno G. Oliveira , Alexandra M. M. Antunes , M. Matilde Marques , Joana S. Rodrigues , Matilde Castro , Sofia A. Pereira , Joana P. Miranda

New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan
TOXICOLOGY LETTERS, 264, 106-113 12 2016
Joao Nunes , Inês Sofia Lança Martins , Catarina Sofia Romão Charneira , Igor P. Pogribny , Aline de Conti , Frederick A. Beland , M. Matilde Marques , Cristina C. Jacob , Alexandra Maria Moita Antunes