| Publication Type |
Journal Article |
| Title |
A new tripodal kojic acid derivative for iron sequestration: Synthesis, protonation, complex formation studies with Fe3+, Al3+, Cu2+ and Zn2+, and in vivo bioassays |
| Authors |
Valeria M. Nurchi Maria de Guadalupe Jaraquemada-Pelaez G. Crisponi J. I. Lachowicz Rosita Cappai Lurdes Gano M. Amélia Santos Andrea Melchior Marilena Tolazzi M. Peana Serenella Medici Maria Antonietta Zoroddu |
| Groups |
BIOIN |
| Journal |
JOURNAL OF INORGANIC BIOCHEMISTRY |
| Year |
2019 |
| Month |
April |
| Volume |
193 |
| Number |
|
| Pages |
152-165 |
| Abstract |
This work presents the simple and low cost synthesis of a new tripodal ligand, in which three units of kojic acid are coupled to a tris(2-aminoethyl)amine (tren) backbone molecule. The protonation equilibria, together with the complex formation equilibria of this ligand with Fe3+, Al3+, Cu2+ and Zn2+ ions were studied. The complementary use of potentiometric, spectrophotometric and NMR techniques, and of Density Functional Theory (DFT) calculations, has allowed a thorough characterization of the different species involved in equilibrium. The stability of the formed complexes with Fe3+ and Al3+ are high enough to consider the new ligand for further studies for its clinical applications as a chelating agent. Biodistribution studies were carried out to assess the capacity the ligand for mobilization of gallium in Ga-67-citrate injected mice. These studies demonstrated that this ligand efficiently chelates the radiometal in our animal model, which suggests that it can be a promising candidate as sequestering agent of iron and other hard trivalent metal ions. Furthermore, the good zinc complexation capacity appears as a stimulating result taking into a potential use of this new ligand in analytical chemistry as well as in agricultural and environmental applications. |
| DOI |
http://dx.doi.org/10.1016/j.jinorgbio.2019.01.012 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
0162-0134 |
| EISSN |
1873-3344 |
| Conference Name |
|
| Bibtex ID |
ISI:000462416600018 |
| Observations |
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