| Publication Type |
Journal Article |
| Title |
A Galactose Dendritic Silicon (IV) Phthalocyanine as a Photosensitizing Agent in Cancer Photodynamic Therapy |
| Authors |
Mafalda Bispo Patricia M. R. Pereira Francesca Setaro M. Salome Rodriguez-Morgade Rosa Fernandes Tomas Torres João P. C. Tomé |
| Groups |
CCC |
| Journal |
CHEMPLUSCHEM |
| Year |
2018 |
| Month |
September |
| Volume |
83 |
| Number |
9 |
| Pages |
855-860 |
| Abstract |
Two protected galacto-dendritic units have been axially coordinated to the central ion of a silicon(IV) phthalocyanine to afford SiPcPGal(4) containing four units of galactose per macrocycle. These biological moieties provided better solubility in aqueous medium and a sensitizer with higher absorption peaks at 680-690 nm. The photodynamic activity of SiPcPGal(4) was evaluated against UM-UC-3 human bladder cancer cell line and the results were compared with the activity of the reported SiPcPGal(2) and SiPc(OH)(2). SiPcPGal(4) had a better uptake and it was a better toxicity inducer than SiPcPGal(2) and SiPc(OH)(2) owing to its four galactose units, protected by isopropylidene groups, which can act as targeted micelles. |
| DOI |
http://dx.doi.org/10.1002/cplu.201800370 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
2192-6506 |
| EISSN |
|
| Conference Name |
|
| Bibtex ID |
ISI:000445850300007 |
| Observations |
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