| Publication Type |
Journal Article |
| Title |
Synthesis and biological evaluation of alpha-hydroxyalkylphosphonates as new antimicrobial agents |
| Authors |
Ana Maria Faisca Phillips Maria Teresa Barros Marta Pacheco Ricardo Dias |
| Groups |
|
| Journal |
BIOORGANIC \& MEDICINAL CHEMISTRY LETTERS |
| Year |
2014 |
| Month |
January |
| Volume |
24 |
| Number |
1 |
| Pages |
49-53 |
| Abstract |
A set of alpha-quaternary 3-chloro-1-hydroxyalkylphosphonates, analogues of fosfomycin and fosfonochlorin, some of which are new compounds, was synthesized. The compounds were screened for bioactivity against several clinical and standard microbial isolates. Some were found to have moderate activity. The activity was higher with phenyl protection of the phosphoryl ester groups and alpha-phenyl substitution. Compound 11 was as effective or more potent than fosfomycin or chloramphenicol against several Gram-negative bacteria as well as against some Gram-positive ones. (C) 2013 Elsevier Ltd. All rights reserved. |
| DOI |
http://dx.doi.org/10.1016/j.bmcl.2013.12.002 |
| ISBN |
|
| Publisher |
|
| Book Title |
|
| ISSN |
0960-894X |
| EISSN |
1464-3405 |
| Conference Name |
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| Bibtex ID |
ISI:000329114200005 |
| Observations |
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