| Publication Type |
Journal Article |
| Title |
Highly water soluble room temperature superionic liquids of APIs |
| Authors |
Goncalo V. S. M. Carrera Miguel M. Santos Alexandra Costa Luis Paulo N. Rebelo Isabel Marrucho M. Nunes da Ponte Luis C. Branco |
| Groups |
MET |
| Journal |
NEW JOURNAL OF CHEMISTRY |
| Year |
2017 |
| Month |
August |
| Volume |
41 |
| Number |
15 |
| Pages |
6986-6990 |
| Abstract |
Herein a straightforward approach for the enhancement of the water solubility of common antibiotic and NSAID active pharmaceutical ingredients (APIs) is presented. The APIs are converted into ionic liquids (API-ILs) and molten salts by combination with the organic superbases TMG, DBU and DBN. The prepared superionic liquids were characterized by H-1 and C-13 NMR as well as FTIR spectroscopy and elemental analysis. Most products are amorphous non-polymorphic room temperature ionic liquids with very high solubility in water, which may enhance the bioavailability of the API-ILs in comparison with the parent drugs. |
| DOI |
http://dx.doi.org/10.1039/c7nj01398a |
| ISBN |
|
| Publisher |
ROYAL SOC CHEMISTRY |
| Book Title |
|
| ISSN |
1144-0546 |
| EISSN |
1369-9261 |
| Conference Name |
|
| Bibtex ID |
ISI:000406192800007 |
| Observations |
|
